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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Diagnosis-Related Groups

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Disease relevance of Diagnosis-Related Groups


Psychiatry related information on Diagnosis-Related Groups


High impact information on Diagnosis-Related Groups

  • When cultured adult DRG cells were treated with antisense oligonucleotides to BDNF, expression of BDNF protein was reduced by 80%, and neuronal survival was reduced by 35% [7].
  • We have used here antisera against tyrosine hydroxylase (TH; EC and dopamine-beta-hydroxylase (DBH; EC, two enzymes specific to catecholaminergic cells, to show that a subpopulation of rat DRG neurones is catecholaminergic and that the neurotransmitter they make is probably dopamine [8].
  • However, after adjusting for diagnosis related group case mix, uninsured patients had, on average, 7% shorter stays (5.36 vs 5.79 days) and underwent 7% fewer procedures (1.16 vs 1.25) than Blue Cross patients, the differences varying with hospital type [9].
  • The Runt-related genes Runx1 and Runx3 are expressed in DRG neuronal subpopulations, suggesting that they may regulate the trajectories of specific axons [10].
  • Here we report that Runx3-deficient (Runx3(-/-)) mice displayed severe motor uncoordination and that few DRG neurons synthesized the proprioceptive neuronal marker parvalbumin [10].

Chemical compound and disease context of Diagnosis-Related Groups


Biological context of Diagnosis-Related Groups

  • Apoptosis of DRG neurons containing peripherin aggregates was dependent on the proinflammatory central nervous system environment of spinal cultures, rich in activated microglia, and required TNF-alpha [16].
  • In response to nerve ligation, persistent and marked up-regulation of CCR2 mRNA was evident in the nerve and DRG [17].
  • Using a neuropathic pain model, chronic compression of the DRG (CCD), we compared anatomically separate populations of noncompressed lumbar DRG (L3/L6) with compressed lumbar DRG (L4/L5) for changes in the gene expression of CCR2 [18].
  • The continued increase in volume can also be accounted for by the mitogenic effect of the RS grafts, since on E4.5 the percentage of thymidine-labeled cells compared with the total cell number in DRG is 28% higher in the polyganglia than in control ganglia [19].
  • Transgene expression recapitulates the spatial endogenous galanin distribution pattern in DRG neurons and markedly overexpresses the peptide in the DRG after nerve injury but not in the uninjured state [20].

Anatomical context of Diagnosis-Related Groups


Associations of Diagnosis-Related Groups with chemical compounds

  • In patch-clamped somata of rat DRG neurons, we found a depolarization-induced membrane capacitance increase (DeltaC(m)) in the absence of extracellular Ca(2+) and in the presence of a Ca(2+) chelator (BAPTA) in the intracellular solution [26].
  • The diacylglycerol kinase inhibitor R59022 enhanced the sustained increase in DRG but did not produce a parallel inhibition in PdtOH production [21].
  • When cultured with NGF, approximately 50% of these adult DRG neurons were capsaicin-sensitive, whereas adult sympathetic neurons or ganglionic nonneuronal cells were insensitive [27].
  • Under whole-cell voltage clamp, kainate and domoate increase membrane conductance in a subpopulation of freshly dissociated DRG neurons [28].
  • Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A [28].

Gene context of Diagnosis-Related Groups

  • By expressing NP-1 in retinal neurons and NP-2 in DRG neurons, we demonstrate that neuropilins are sufficient to determine the functional specificity of semaphorin responsiveness [29].
  • We show that mRNA and protein for the GDNF receptor tyrosine kinase, Ret, are expressed in the DRG in patterns that differ markedly from those of any of the neurotrophin receptors [11].
  • In DRG neurons, this mechanism was found to lead to TRPV1-mediated currents that were enhanced by selective blockade of anandamide cellular efflux [30].
  • Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) both supported neurite outgrowth from DRG explanted from all segmental levels [31].
  • This work provides direct evidence for a potential role of NT-3 versus NGF in the survival of a specific subpopulation of DRG neurons [31].

Analytical, diagnostic and therapeutic context of Diagnosis-Related Groups


  1. A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Khasar, S.G., Lin, Y.H., Martin, A., Dadgar, J., McMahon, T., Wang, D., Hundle, B., Aley, K.O., Isenberg, W., McCarter, G., Green, P.G., Hodge, C.W., Levine, J.D., Messing, R.O. Neuron (1999) [Pubmed]
  2. Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule. Kunz, S., Spirig, M., Ginsburg, C., Buchstaller, A., Berger, P., Lanz, R., Rader, C., Vogt, L., Kunz, B., Sonderegger, P. J. Cell Biol. (1998) [Pubmed]
  3. Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: Protease inhibitor-mediated neurotoxicity. Pettersen, J.A., Jones, G., Worthington, C., Krentz, H.B., Keppler, O.T., Hoke, A., Gill, M.J., Power, C. Ann. Neurol. (2006) [Pubmed]
  4. Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia: pathogenic effects of STAT-1 and inducible nitric oxide synthase. Zhu, Y., Jones, G., Tsutsui, S., Opii, W., Liu, S., Silva, C., Butterfield, D.A., Power, C. J. Immunol. (2005) [Pubmed]
  5. Gene transfer to dorsal root ganglia by intrathecal injection: effects on regeneration of peripheral nerves. Wang, X., Wang, C., Zeng, J., Xu, X., Hwang, P.Y., Yee, W.C., Ng, Y.K., Wang, S. Mol. Ther. (2005) [Pubmed]
  6. Stat testing and DRGs: a strategy for cost containment. Sazama, K. Pathologist. (1985) [Pubmed]
  7. A BDNF autocrine loop in adult sensory neurons prevents cell death. Acheson, A., Conover, J.C., Fandl, J.P., DeChiara, T.M., Russell, M., Thadani, A., Squinto, S.P., Yancopoulos, G.D., Lindsay, R.M. Nature (1995) [Pubmed]
  8. A subpopulation of rat dorsal root ganglion neurones is catecholaminergic. Price, J., Mudge, A.W. Nature (1983) [Pubmed]
  9. Case mix and resource utilization by uninsured hospital patients in the Boston metropolitan area. Weissman, J., Epstein, A.M. JAMA (1989) [Pubmed]
  10. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Inoue, K., Ozaki, S., Shiga, T., Ito, K., Masuda, T., Okado, N., Iseda, T., Kawaguchi, S., Ogawa, M., Bae, S.C., Yamashita, N., Itohara, S., Kudo, N., Ito, Y. Nat. Neurosci. (2002) [Pubmed]
  11. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Molliver, D.C., Wright, D.E., Leitner, M.L., Parsadanian, A.S., Doster, K., Wen, D., Yan, Q., Snider, W.D. Neuron (1997) [Pubmed]
  12. Ca2+ sparks and secretion in dorsal root ganglion neurons. Ouyang, K., Zheng, H., Qin, X., Zhang, C., Yang, D., Wang, X., Wu, C., Zhou, Z., Cheng, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity. Holz, G.G., Dunlap, K., Kream, R.M. J. Neurosci. (1988) [Pubmed]
  14. Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons. Sohrabji, F., Miranda, R.C., Toran-Allerand, C.D. J. Neurosci. (1994) [Pubmed]
  15. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. Hong, S., Wiley, J.W. J. Biol. Chem. (2005) [Pubmed]
  16. Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha. Robertson, J., Beaulieu, J.M., Doroudchi, M.M., Durham, H.D., Julien, J.P., Mushynski, W.E. J. Cell Biol. (2001) [Pubmed]
  17. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Abbadie, C., Lindia, J.A., Cumiskey, A.M., Peterson, L.B., Mudgett, J.S., Bayne, E.K., DeMartino, J.A., MacIntyre, D.E., Forrest, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  18. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. White, F.A., Sun, J., Waters, S.M., Ma, C., Ren, D., Ripsch, M., Steflik, J., Cortright, D.N., Lamotte, R.H., Miller, R.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  19. The microenvironment created by grafting rostral half-somites is mitogenic for neural crest cells. Goldstein, R.S., Teillet, M.A., Kalcheim, C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  20. Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Holmes, F.E., Bacon, A., Pope, R.J., Vanderplank, P.A., Kerr, N.C., Sukumaran, M., Pachnis, V., Wynick, D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  21. Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol. Bourgoin, S., Plante, E., Gaudry, M., Naccache, P.H., Borgeat, P., Poubelle, P.E. J. Exp. Med. (1990) [Pubmed]
  22. Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. McMahon, S.B., Armanini, M.P., Ling, L.H., Phillips, H.S. Neuron (1994) [Pubmed]
  23. Down-regulation of myelin-associated glycoprotein on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth. Schneider-Schaulies, J., Kirchhoff, F., Archelos, J., Schachner, M. Neuron (1991) [Pubmed]
  24. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Cai, D., Deng, K., Mellado, W., Lee, J., Ratan, R.R., Filbin, M.T. Neuron (2002) [Pubmed]
  25. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. Trupp, M., Rydén, M., Jörnvall, H., Funakoshi, H., Timmusk, T., Arenas, E., Ibáñez, C.F. J. Cell Biol. (1995) [Pubmed]
  26. Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Zhang, C., Zhou, Z. Nat. Neurosci. (2002) [Pubmed]
  27. Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin. Winter, J., Forbes, C.A., Sternberg, J., Lindsay, R.M. Neuron (1988) [Pubmed]
  28. Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A. Huettner, J.E. Neuron (1990) [Pubmed]
  29. Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Takahashi, T., Nakamura, F., Jin, Z., Kalb, R.G., Strittmatter, S.M. Nat. Neurosci. (1998) [Pubmed]
  30. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. van der Stelt, M., Trevisani, M., Vellani, V., De Petrocellis, L., Schiano Moriello, A., Campi, B., McNaughton, P., Geppetti, P., Di Marzo, V. EMBO J. (2005) [Pubmed]
  31. Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture. Hory-Lee, F., Russell, M., Lindsay, R.M., Frank, E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  32. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. Obata, K., Katsura, H., Mizushima, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Tokunaga, A., Tominaga, M., Noguchi, K. J. Clin. Invest. (2005) [Pubmed]
  33. Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Alvarez de la Rosa, D., Zhang, P., Shao, D., White, F., Canessa, C.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  34. Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomy. Zhang, X., Xu, Z.Q., Bao, L., Dagerlind, A., Hökfelt, T. J. Neurosci. (1995) [Pubmed]
  35. NGF rescues substance P expression but not neurofilament or tubulin gene expression in axotomized sensory neurons. Wong, J., Oblinger, M.M. J. Neurosci. (1991) [Pubmed]
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