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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SCAF11  -  SR-related CTD-associated factor 11

Homo sapiens

Synonyms: CASP11, CTD-associated SR protein 11, Protein SCAF11, Renal carcinoma antigen NY-REN-40, SC35-interacting protein 1, ...
 
 
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Disease relevance of SFRS2IP

  • IgM immunoreactivity to Sip1 C-ter was significantly higher in patients with Behçet's disease and in patients with primary vasculitis than in the other groups of patients and healthy subjects tested (P < 10-4 by Mann-Whitney test) [1].
 

High impact information on SFRS2IP

  • Deficiency in the formation of both A and B splicing complexes in the Sip1-depleted nuclear extract indicates an important role of Sip1 in spliceosome assembly [2].
  • The DNA fragment library of the SRrp129 clone was then used in the yeast two-hybrid system to identify the 100-amino acid domain that interacts with the CTD of RNA polymerase II [3].
  • We screened a cDNA library from human microvascular endothelial cells with serum IgG from two patients with Behçet's disease and isolated a reactive clone specific to the carboxy-terminal subunit of Sip1 (Sip1 C-ter) [1].
 

Analytical, diagnostic and therapeutic context of SFRS2IP

  • ELISA detected IgG specific to Sip1 C-ter in sera from 11/56 (20%) patients with Behçet's disease, IgM in 23/56 (41%) and IgA in 9/54 (17%) [1].

References

  1. Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behçet's disease. Delunardo, F., Conti, F., Margutti, P., Alessandri, C., Priori, R., Siracusano, A., Riganò, R., Profumo, E., Valesini, G., Sorice, M., Ortona, E. Arthritis Res. Ther. (2006) [Pubmed]
  2. Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. Zhang, W.J., Wu, J.Y. Mol. Cell. Biol. (1998) [Pubmed]
  3. A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain. Tanner, S., Stagljar, I., Georgiev, O., Schaffner, W., Bourquin, J.P. Biol. Chem. (1997) [Pubmed]
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