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Gene Review:

Scaf11 - SR-related CTD-associated factor 11

Mus musculus

Synonyms: 1110061H03Rik, 2610510E10Rik, AI462454, CASP11, SIP1, ...

Wang, S. et al., Schotte, P. et al.

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Disease relevance of Sfrs2ip

Like Ice-deficient mice, casp-11 mutant mice are resistant to endotoxic shock induced by lipopolysaccharide [1].

High impact information on Sfrs2ip

Furthermore, we found that pro-caspase-11 physically interacts with pro-ICE in cells, and the expression of casp-11 is essential for activation of ICE [1].
We report here the inactivation of a member of the Ice/Ced-3 (caspase) family of cell death genes, casp-11, by gene targeting [1].
Production of both IL-1alpha and IL-1beta after lipopolysaccharide stimulation, a crucial event during septic shock and an indication of ICE activation, is blocked in casp-11 mutant mice. casp-11 mutant embryonic fibroblast cells are resistant to apoptosis induced by overexpression of ICE [1].
Analysis of subcellular fractions for their ability to process and activate several caspases in vitro led to the identification of lysosomes as the source for a protease that could proteolytically activate the proinflammatory CASP-11 [2].

References

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998) [Pubmed]
Cathepsin B-mediated activation of the proinflammatory caspase-11. Schotte, P., Van Criekinge, W., Van de Craen, M., Van Loo, G., Desmedt, M., Grooten, J., Cornelissen, M., De Ridder, L., Vandekerckhove, J., Fiers, W., Vandenabeele, P., Beyaert, R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]

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