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Gene Review

ZMYM4  -  zinc finger, MYM-type 4

Homo sapiens

Synonyms: CDIR, KIAA0425, MYM, ZNF198L3, ZNF262, ...
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Disease relevance of ZMYM4


High impact information on ZMYM4

  • Among the elements that inhibited interferon-gamma-induced apoptosis of HeLa cells was a 441-nucleotide fragment derived from the 3'-untranslated region (UTR) of KIAA0425, a gene of unknown function [2].
  • The predicted protein products of ZNF258 and ZNF262 maintain the repeats of the MYM motif [3].
  • It is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing, including a large 382 amino acid form containing a single MYM domain, and 2 shorter forms of 208 and 213 amino acids respectively that do not [4].
  • Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization [5].
  • We have previously demonstrated that overexpression of Cell Death Inhibiting RNA (CDIR), a portion of the 3'untranslated region (UTR) of KIAA0425, inhibits Interferon-gamma (IFN-gamma) induced apoptosis in HeLa cells (Shchors et al., J Biol Chem 2002; 277:47061-72) [6].


  1. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. McDoniels-Silvers, A.L., Nimri, C.F., Stoner, G.D., Lubet, R.A., You, M. Clin. Cancer Res. (2002) [Pubmed]
  2. Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27. Shchors, K., Yehiely, F., Kular, R.K., Kotlo, K.U., Brewer, G., Deiss, L.P. J. Biol. Chem. (2002) [Pubmed]
  3. Cloning and mapping of members of the MYM family. Smedley, D., Hamoudi, R., Lu, Y.J., Cooper, C., Shipley, J. Genomics (1999) [Pubmed]
  4. Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM. Pastorcic, M., Das, H.K. Brain Res. (2007) [Pubmed]
  5. Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization. Sohal, J., Chase, A., Goldman, J.M., Cross, N.C. Cytogenet. Cell Genet. (1999) [Pubmed]
  6. Cell Death Inhibiting RNA (CDIR) modulates IFN-gamma-stimulated sensitization to Fas/CD95/Apo-1 and TRAIL/Apo-2L-induced apoptosis. Shchors, K., Yehiely, F., Deiss, L.P. Cell Cycle (2004) [Pubmed]
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