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Gene Review:

ORF60 - contains a signal peptide; complexed with...

Cercopithecine herpesvirus 9

Ashburn, C.V. et al., Nĕmecková, S. et al., Ashburn, C.V. et al.

Nĕmecková, Ludvíková, Maresová, Krystofová, Hainz, Kutinová,

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Disease relevance of ORF60

Expression of the simian varicella virus glycoprotein L and H [1].
The SVV gL gene encodes a predicted 175 amino acid polypeptide that shares 43.5% and 27.9% amino acid identity with the VZV gL and HSV-1 gL, respectively [1].
Induction of varicella-zoster virus-neutralizing antibodies in mice by co-infection with recombinant vaccinia viruses expressing the gH or gL gene [2].

High impact information on ORF60

The SVV gL polypeptide sequence lacks a consensus glycosylation site and a typical signal sequence, but does possess an endoplasmic reticulum targeting sequence found commonly in chaperone proteins [1].
The SVV UDG is encoded on a 2.0 kb transcript which also appears to encode the SVV glycoprotein L (gL) and the VZV gene 58 homolog [3].

References

Expression of the simian varicella virus glycoprotein L and H. Ashburn, C.V., Gray, W.L. Arch. Virol. (2002) [Pubmed]
Induction of varicella-zoster virus-neutralizing antibodies in mice by co-infection with recombinant vaccinia viruses expressing the gH or gL gene. Nĕmecková, S., Ludvíková, V., Maresová, L., Krystofová, J., Hainz, P., Kutinová, L. J. Gen. Virol. (1996) [Pubmed]
Identification and characterization of the simian varicella virus uracil DNA glycosylase. Ashburn, C.V., Gray, W.L. Arch. Virol. (1999) [Pubmed]

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