Gene Review:
ORF59 - uracil DNA glycosylase
Cercopithecine herpesvirus 9
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Disease relevance of ORF59
- Identification and characterization of the simian varicella virus uracil DNA glycosylase [1].
High impact information on ORF59
- The SVV UDG is encoded on a 2.0 kb transcript which also appears to encode the SVV glycoprotein L (gL) and the VZV gene 58 homolog [1].
- Uracil DNA glycosylase (UDG) is a DNA repair enzyme responsible for excision of uracil residues misincorporated into DNA [1].
- The SVV UDG is expressed in infected Vero cells as determined by reverse transcriptase polymerase chain reaction (RT-PCR) and Northern blot analysis [1].
- The SVV UDG is enzymatically active as determined by the ability of a SVV UDG-maltose binding protein fusion construct to remove [(3)H]-uracil incorporated into DNA [1].
References
- Identification and characterization of the simian varicella virus uracil DNA glycosylase. Ashburn, C.V., Gray, W.L. Arch. Virol. (1999) [Pubmed]
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