Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

LRRFIP2 - leucine rich repeat (in FLII) interacting...

Homo sapiens

Synonyms: HUFI-2, LRR FLII-interacting protein 2, Leucine-rich repeat flightless-interacting protein 2

Fong, K.S. et al., Liu, J. et al.

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High impact information on LRRFIP2

Expression of LRRFIP2 in Xenopus embryos induced double axis formation and Wnt target gene expression; a dominant negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation [1].
LRRFIP1 and LRRFIP2 both express alternative splice variants in heart and skeletal muscle tissue [2].
Sequencing and PCR-directed genomic analysis indicate that LRRFIP1 and LRRFIP2 are related genes that arose from gene duplication [2].

Biological context of LRRFIP2

LRRFIP2 is a novel gene that shares sequence homology with LRRFIP1 and FLAP-1 [2].

References

Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Liu, J., Bang, A.G., Kintner, C., Orth, A.P., Chanda, S.K., Ding, S., Schultz, P.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. Fong, K.S., de Couet, H.G. Genomics (1999) [Pubmed]

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