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LRRFIP1  -  leucine rich repeat (in FLII) interacting...

Homo sapiens

Synonyms: FLAP-1, FLAP1, FLIIAP1, GC-binding factor 2, GCF-2, ...
 
 
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Disease relevance of LRRFIP1

  • GCF2 expressed in vitro using reticulocyte lysates and Escherichia coli migrates as a 160-kilodalton protein in SDS-polyacrylamide gel electrophoresis but has a molecular mass of 83 kilodaltons as determined by mass spectrum analysis [1].
  • CONCLUSIONS: Flap selection and the appropriate short- and long-term sequence of flap use significantly improve success rates for pressure sore coverage [2].
  • CONCLUSIONS: Flap dislodgment and wrinkling are serious postoperative complications of LASIK [3].
  • Reply to Dr Nuhoğlu et al.'s Letter to the Editor re: Miroslav L. Djordjevic, Sava V. Perovic, Zoran Slavkovic and Nenad Djakovic. Longitudinal Dorsal Dartos Flap for Prevention of Fistula after a Snodgrass Hypospadias Procedure. Eur Urol 2006;50:53-57 [4].
  • Repair of Basal Cell Carcinoma on the Outer Canthus via a Bifurcated Island Flap [5].
 

High impact information on LRRFIP1

  • GCF2/LRRFIP1 is the first TNF-alpha repressor identified [6].
  • GCF2 binds to epidermal growth factor receptor promoter fragments, and the major binding site is located between nucleotides -249 and -233 [1].
  • Drastic conformational changes associated with flavin binding are observed primarily at the so-called Flap I and Flap II loop regions [7].
  • The conformational changes in Flap I resulted in a new Mg(2+) coordination pattern in which a FMN phosphate oxygen and Asn36 side chain carbonyl are directly coordinating to the Mg(2+) ion [7].
  • PARTICIPANTS: Individual eyes of 19 consecutive patients with moderate to severe punctate epithelial erosions and rose bengal staining on the flap 1 to 3 months after LASIK were compared with eyes of 19 concurrent patients who did not have punctate epithelial erosions or more than trace staining on the flap develop [8].
 

Biological context of LRRFIP1

 

Anatomical context of LRRFIP1

 

Associations of LRRFIP1 with chemical compounds

  • Tests showed that the Flap Neck Shield behaved in a biofidelic manner with neck loads and head motion within established biofidelic limits [15].
  • The lithium complexes Ar(C6H4-2-CH2NMe2)PLi undergo metathesis reactions with either NaOBut or KOBut to give the heavier alkali metal phosphides {Ar(C6H4-2-CH2NMe2)P}M.1/2OEt2 [Ar = mes, M = Na (8), K (9); Ar = Tripp, M = K (10)] [16].
 

Other interactions of LRRFIP1

  • We report the identification of two related genes, LRRFIP1 and LRRFIP2, encoding proteins that interact with the LRR domain of human FLI using the yeast two-hybrid system [9].
 

Analytical, diagnostic and therapeutic context of LRRFIP1

  • CONCLUSION: Flap procedures for breast reconstruction stimulate the pro-inflammatory response [17].
  • Figure-of-Eight Vertical Mattress Suture Technique for Anterior Flap Suspension to Overlying Tissues in External Dacryocystorhinostomy [18].
  • TRAM Flap for Immediate Post Mastectomy Reconstruction: Comparison between Pedicled and Free Transfer [19].
  • In the Douible Flap Scheie a conjunctival and scleral flap are made followed by a cornea-scleral cauterization and incision after which a peripheral iridectomy is made [20].
  • Comparison of Local Recurrence and Distant Metastases between Breast Cancer Patients after Postmastectomy Radiotherapy with and without Immediate TRAM Flap Reconstruction [21].

References

  1. Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor. Reed, A.L., Yamazaki, H., Kaufman, J.D., Rubinstein, Y., Murphy, B., Johnson, A.C. J. Biol. Chem. (1998) [Pubmed]
  2. Flap selection as a determinant of success in pressure sore coverage. Foster, R.D., Anthony, J.P., Mathes, S.J., Hoffman, W.Y., Young, D., Eshima, I. Archives of surgery (Chicago, Ill. : 1960) (1997) [Pubmed]
  3. Management of severe flap wrinkling or dislodgment after laser in situ keratomileusis. Lam, D.S., Leung, A.T., Wu, J.T., Cheng, A.C., Fan, D.S., Rao, S.K., Talamo, J.H., Barraquer, C. Journal of cataract and refractive surgery. (1999) [Pubmed]
  4. Reply to Dr Nuhoğlu et al.'s Letter to the Editor re: Miroslav L. Djordjevic, Sava V. Perovic, Zoran Slavkovic and Nenad Djakovic. Longitudinal Dorsal Dartos Flap for Prevention of Fistula after a Snodgrass Hypospadias Procedure. Eur Urol 2006;50:53-57. Djordjevic, M. Eur. Urol. (2007) [Pubmed]
  5. Repair of Basal Cell Carcinoma on the Outer Canthus via a Bifurcated Island Flap. Wu, X., Qian, G., Fang, F. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2006) [Pubmed]
  6. GCF2/LRRFIP1 represses tumor necrosis factor alpha expression. Suriano, A.R., Sanford, A.N., Kim, N., Oh, M., Kennedy, S., Henderson, M.J., Dietzmann, K., Sullivan, K.E. Mol. Cell. Biol. (2005) [Pubmed]
  7. Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism. Karthikeyan, S., Zhou, Q., Osterman, A.L., Zhang, H. Biochemistry (2003) [Pubmed]
  8. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Wilson, S.E. Ophthalmology (2001) [Pubmed]
  9. Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. Fong, K.S., de Couet, H.G. Genomics (1999) [Pubmed]
  10. Effect of suturing on latrogenic keratectasia after laser in situ keratomileusis. Seo, K.Y., Lee, J.H., Kim, M.J., Park, J.W., Chung, E.S., Lee, Y.S., Kim, E.K. Journal of refractive surgery (Thorofare, N.J. : 1995) (2004) [Pubmed]
  11. PACAP Induces Neurite Outgrowth in Cultured Trigeminal Ganglion Cells and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits. Fukiage, C., Nakajima, T., Takayama, Y., Minagawa, Y., Shearer, T.R., Azuma, M. Am. J. Ophthalmol. (2007) [Pubmed]
  12. The Superficial Inferior Epigastric Artery (SIEA) Flap: Indications for Breast Reconstruction. Wolfram, D., Schoeller, T., Hussl, H., Wechselberger, G. Annals of plastic surgery (2006) [Pubmed]
  13. Toynbee Memorial Lecture 1994: mastoid surgery and the Hong Kong Flap. van Hasselt, C.A. The Journal of laryngology and otology. (1994) [Pubmed]
  14. The Hong Kong vascularized temporalis fascia flaps for optimal, mastoid cavity reconstruction. Van Hasselt, C.A., Liu, K.C., Tong, M.C. Revue de laryngologie - otologie - rhinologie. (1995) [Pubmed]
  15. Development and Evaluation of a Proposed Neck Shield for the 5 Percentile Hybrid III Female Dummy. Banglmaier, R.F., Pecoraro, K.M., Feustel, J.R., Scherer, R.D., Rouhana, S.W. Stapp car crash journal (2005) [Pubmed]
  16. Amino-functionalised diarylphosphide complexes of the alkali metals and lanthanum. Izod, K., Liddle, S.T., Clegg, W., Harrington, R.W. Dalton transactions (Cambridge, England : 2003) (2006) [Pubmed]
  17. Pro-inflammatory cytokines in elective flap surgery. Schmidt, A., Bengtsson, A., Tylman, M., Blomqvist, L. J. Surg. Res. (2007) [Pubmed]
  18. Figure-of-Eight Vertical Mattress Suture Technique for Anterior Flap Suspension to Overlying Tissues in External Dacryocystorhinostomy. Evereklioglu, C., Oner, A., Somdaş, M.A., Ketenci, I., Dogan, H., Mirza, E., Ilhan, O. Am. J. Ophthalmol. (2007) [Pubmed]
  19. TRAM Flap for Immediate Post Mastectomy Reconstruction: Comparison between Pedicled and Free Transfer. Bassiouny, M.M., Maamoun, S.I., El-Shazly, S.e.l.-.D., Youssef, O.Z. Journal of the Egyptian National Cancer Institute (2005) [Pubmed]
  20. Four year follow-up of a glaucoma operation. Prospective study of the double flap Scheie. Greve, E.L., Dake, C.L. International ophthalmology. (1979) [Pubmed]
  21. Comparison of Local Recurrence and Distant Metastases between Breast Cancer Patients after Postmastectomy Radiotherapy with and without Immediate TRAM Flap Reconstruction. Huang, C.J., Hou, M.F., Lin, S.D., Chuang, H.Y., Huang, M.Y., Fu, O.Y., Lian, S.L. Plast. Reconstr. Surg. (2006) [Pubmed]
 
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