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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DHRS3  -  dehydrogenase/reductase (SDR family) member 3

Homo sapiens

Synonyms: DD83.1, RDH17, Retinal short-chain dehydrogenase/reductase 1, Rsdr1, SDR1, ...
 
 
 
 
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Disease relevance of DHRS3

 

High impact information on DHRS3

  • Our observations suggest that retSDR1 is a novel regulator of vitamin A metabolism and that its frequent deletion in NB cells bearing MYCN amplification could compromise the sensitivity of those cells to retinol, thereby contributing to cancer development and progression [1].
  • DD83.1 is identical to the human retSDR1, a short chain dehydrogenase/reductase that is thought to regenerate retinol from retinal in the visual cycle [1].
  • Here we report on the characterization of one of them (DD83.1) in NB cell lines [1].
  • Both the retinoic acid-dependent and the exogenous expression of retSDR1 in SK-N-AS cells induce the accumulation of retinyl esters, which indicates that it is involved in generating storage forms of retinol in tissues exposed to physiological retinol concentrations [1].

References

  1. retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines. Cerignoli, F., Guo, X., Cardinali, B., Rinaldi, C., Casaletto, J., Frati, L., Screpanti, I., Gudas, L.J., Gulino, A., Thiele, C.J., Giannini, G. Cancer Res. (2002) [Pubmed]
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