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Gene Review

ADH7  -  alcohol dehydrogenase 7 (class IV), mu or...

Homo sapiens

Synonyms: ADH-4, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase
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Disease relevance of ADH7


Psychiatry related information on ADH7


High impact information on ADH7


Biological context of ADH7

  • A nearly full-length cDNA for ADH7 was isolated from a human stomach cDNA library, and a 5' genomic clone containing exons 1 and 2 was isolated from a human genomic library [12].
  • The ADH7 gene encoding human Class IV (sigma) alcohol dehydrogenase (ADH) was cloned from a Caucasian genomic DNA library and characterized [13].
  • Fluorescence in situ hybridization analysis showed that ADH7 is located on human chromosome 4q23-q24, close to the ADH cluster locus (4q21-q25) [13].
  • The deduced amino acid sequence shows 59-70% identities with the other human ADH classes, demonstrating that the stomach enzyme represents a distinct structure, constituting class IV, coded by a separate gene, ADH7 [14].
  • We observed nominally significant pairwise linkage disequilibrium, in some populations, between the ADH7 site and some Class I ADH sites, at moderate values and at a molecular distance as great as 100 kb [15].

Anatomical context of ADH7


Associations of ADH7 with chemical compounds

  • Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro [20].
  • BACKGROUND: Of the seven known human alcohol dehydrogenase (ADH) genes, the non-liver expressed ADH7 gene codes for the enzyme with the highest maximal activity for ethanol [21].
  • A recent study in a Japanese subject found a point mutation in the codon for amino acid 287 of the ADH7 gene (which encodes sigma-ADH), changing the amino acid from glycine to valine [22].
  • Retinoic acid regulation of one member of the human class I alcohol dehydrogenase (ADH) gene family was demonstrated, suggesting that the retinol dehydrogenase function of ADH may play a regulatory role in the biosynthetic pathway for retinoic acid [23].
  • Cell culture studies support a role for RoDH-4 as a retinol dehydrogenase and for AKR1B1 as a retinaldehyde reductase in vivo [24].

Regulatory relationships of ADH7


Other interactions of ADH7


Analytical, diagnostic and therapeutic context of ADH7


  1. Frequencies of single nucleotide polymorphism in alcohol dehydrogenase7 gene in patients with multiple system atrophy and controls. Kim, H.S., Lee, M.S. Mov. Disord. (2003) [Pubmed]
  2. retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines. Cerignoli, F., Guo, X., Cardinali, B., Rinaldi, C., Casaletto, J., Frati, L., Screpanti, I., Gudas, L.J., Gulino, A., Thiele, C.J., Giannini, G. Cancer Res. (2002) [Pubmed]
  3. The effect of gastritis on human gastric alcohol dehydrogenase activity and ethanol metabolism. Brown, A.S., Fiatarone, J.R., Wood, P., Bennett, M.K., Kelly, P.J., Rawlins, M.D., Day, C.P., James, O.F. Aliment. Pharmacol. Ther. (1995) [Pubmed]
  4. A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium. Rexer, B.N., Ong, D.E. Biol. Reprod. (2002) [Pubmed]
  5. Influence of age, sex, and Helicobacter pylori infection before and after eradication on gastric alcohol dehydrogenase activity. Kechagias, S., Jönsson , K.A., Borch, K., Jones, A.W. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  6. Gastric alcohol dehydrogenase activity in man: influence of gender, age, alcohol consumption and smoking in a caucasian population. Parlesak, A., Billinger, M.H., Bode, C., Bode, J.C. Alcohol Alcohol. (2002) [Pubmed]
  7. Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy. Janecke, A.R., Thompson, D.A., Utermann, G., Becker, C., Hübner, C.A., Schmid, E., McHenry, C.L., Nair, A.R., Rüschendorf, F., Heckenlively, J., Wissinger, B., Nürnberg, P., Gal, A. Nat. Genet. (2004) [Pubmed]
  8. Aspirin increases blood alcohol concentrations in humans after ingestion of ethanol. Roine, R., Gentry, R.T., Hernández-Munõz, R., Baraona, E., Lieber, C.S. JAMA (1990) [Pubmed]
  9. PPAR{gamma} controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. Szatmari, I., Pap, A., R??hl, R., Ma, J.X., Illarionov, P.A., Besra, G.S., Rajnavolgyi, E., Dezso, B., Nagy, L. J. Exp. Med. (2006) [Pubmed]
  10. Alcohol and the liver: 1994 update. Lieber, C.S. Gastroenterology (1994) [Pubmed]
  11. Effects of cimetidine on gastric alcohol dehydrogenase activity and blood ethanol levels. Caballeria, J., Baraona, E., Rodamilans, M., Lieber, C.S. Gastroenterology (1989) [Pubmed]
  12. The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. Satre, M.A., Zgombić-Knight, M., Duester, G. J. Biol. Chem. (1994) [Pubmed]
  13. Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH. Yokoyama, H., Baraona, E., Lieber, C.S. Genomics (1996) [Pubmed]
  14. Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. Farrés, J., Moreno, A., Crosas, B., Peralba, J.M., Allali-Hassani, A., Hjelmqvist, L., Jörnvall, H., Parés, X. Eur. J. Biochem. (1994) [Pubmed]
  15. A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Osier, M.V., Pakstis, A.J., Soodyall, H., Comas, D., Goldman, D., Odunsi, A., Okonofua, F., Parnas, J., Schulz, L.O., Bertranpetit, J., Bonne-Tamir, B., Lu, R.B., Kidd, J.R., Kidd, K.K. Am. J. Hum. Genet. (2002) [Pubmed]
  16. Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase. Chai, X., Boerman, M.H., Zhai, Y., Napoli, J.L. J. Biol. Chem. (1995) [Pubmed]
  17. Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. Rattner, A., Smallwood, P.M., Nathans, J. J. Biol. Chem. (2000) [Pubmed]
  18. Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1. Zhang, M., Hu, P., Napoli, J.L. J. Biol. Chem. (2004) [Pubmed]
  19. Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. Hardy, D.O., Ge, R.S., Catterall, J.F., Hou, Y.T., Penning, T.M., Hardy, M.P. Endocrinology (2000) [Pubmed]
  20. Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. Zgombić-Knight, M., Foglio, M.H., Duester, G. J. Biol. Chem. (1995) [Pubmed]
  21. Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. Han, Y., Oota, H., Osier, M.V., Pakstis, A.J., Speed, W.C., Odunsi, A., Okonofua, F., Kajuna, S.L., Karoma, N.J., Kungulilo, S., Grigorenko, E., Zhukova, O.V., Bonne-Tamir, B., Lu, R.B., Parnas, J., Schulz, L.O., Kidd, J.R., Kidd, K.K. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  22. Failure to find exon 7 polymorphism of the ADH7 gene in Chinese, Japanese, African-Americans, and Caucasians. Carr, L.G., Zeng, D., Li, T.K. Alcohol. Clin. Exp. Res. (1996) [Pubmed]
  23. Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis. Duester, G., Shean, M.L., McBride, M.S., Stewart, M.J. Mol. Cell. Biol. (1991) [Pubmed]
  24. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. Gallego, O., Belyaeva, O.V., Porté, S., Ruiz, F.X., Stetsenko, A.V., Shabrova, E.V., Kostereva, N.V., Farrés, J., Parés, X., Kedishvili, N.Y. Biochem. J. (2006) [Pubmed]
  25. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. Jette, C., Peterson, P.W., Sandoval, I.T., Manos, E.J., Hadley, E., Ireland, C.M., Jones, D.A. J. Biol. Chem. (2004) [Pubmed]
  26. Differential activity of the promoter for the human alcohol dehydrogenase (retinol dehydrogenase) gene ADH3 in neural tube of transgenic mouse embryos. Zgombić-Knight, M., Satre, M.A., Duester, G. J. Biol. Chem. (1994) [Pubmed]
  27. Alcohol dehydrogenase alleles in Parkinson's disease. Buervenich, S., Sydow, O., Carmine, A., Zhang, Z., Anvret, M., Olson, L. Mov. Disord. (2000) [Pubmed]
  28. Disease-causing mutations in the cellular retinaldehyde binding protein tighten and abolish ligand interactions. Golovleva, I., Bhattacharya, S., Wu, Z., Shaw, N., Yang, Y., Andrabi, K., West, K.A., Burstedt, M.S., Forsman, K., Holmgren, G., Sandgren, O., Noy, N., Qin, J., Crabb, J.W. J. Biol. Chem. (2003) [Pubmed]
  29. Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Wu, B.X., Moiseyev, G., Chen, Y., Rohrer, B., Crouch, R.K., Ma, J.X. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  30. Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7). Yokoyama, S., Matsuo, Y., Ramsbotham, R., Yokoyama, R. FEBS Lett. (1994) [Pubmed]
  31. Identification of new single nucleotid polymorphisms (SNP) in alcohol dehydrogenase class IV ADH7 gene within a French population. Abbas, A., Lechevrel, M., Sichel, F. Arch. Toxicol. (2006) [Pubmed]
  32. Effects of Helicobacter pylori infection and gastritis on gastric alcohol dehydrogenase activity. Thuluvath, P., Wojno, K.J., Yardley, J.H., Mezey, E. Alcohol. Clin. Exp. Res. (1994) [Pubmed]
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