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TIFA  -  TRAF-interacting protein with forkhead...

Homo sapiens

Synonyms: MGC20791, T2BP, T6BP, TIFAA, TRAF-interacting protein with FHA domain-containing protein A, ...
 
 
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High impact information on TIFA

  • Importantly, TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism [1].
  • In transient transfection assays, TIFA activates NFkappaBeta and c-Jun amino-terminal kinase [2].
  • Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA [3].
  • TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain [4].
  • TIFAB does not associate with members of the TRAF family but does bind TIFA [4].
 

Physical interactions of TIFA

 

Regulatory relationships of TIFA

  • TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 [1].
 

Other interactions of TIFA

  • We show that recombinant TIFA protein, but not TRAF6-binding-defective mutant, can activate IKK in crude cytosolic extracts [1].
  • We report identification of a TIFA-related protein, TIFAB, that inhibits TIFA-mediated activation of NFkappaB [4].
  • Our results suggest that T2BP is involved in the TNF-mediated signaling by its interaction with TRAF2 [6].

References

  1. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Ea, C.K., Sun, L., Inoue, J., Chen, Z.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. Takatsuna, H., Kato, H., Gohda, J., Akiyama, T., Moriya, A., Okamoto, Y., Yamagata, Y., Otsuka, M., Umezawa, K., Semba, K., Inoue, J. J. Biol. Chem. (2003) [Pubmed]
  3. Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA. Inoue, J., Yagi, S., Ishikawa, K., Azuma, S., Ikawa, S., Semba, K. Gene (2005) [Pubmed]
  4. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain. Matsumura, T., Semba, K., Azuma, S., Ikawa, S., Gohda, J., Akiyama, T., Inoue, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. Molecular cloning of TRAF2 binding protein gene and its promoter region from the grass carp Ctenopharyngodon idellus. Chang, M.X., Nie, P., Sun, B.J., Yao, W.J. Vet. Immunol. Immunopathol. (2005) [Pubmed]
  6. T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation. Kanamori, M., Suzuki, H., Saito, R., Muramatsu, M., Hayashizaki, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
 
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