Disease relevance of TANK

• These results suggested that variation of I-TRAF might be an important determinant for postmenopausal osteoporosis [1].
• Viral reservoirs/transient infection in HIV/AIDS: where are we now and where should we go? Summary of the June 13-14, 2002 Think Tank meeting [2].
• Exfoliation (pseudoexfoliation) syndrome: toward a new understanding. Proceedings of the First International Think Tank [3].

High impact information on TANK

• We report the identification of a TRAF-interacting protein, T6BP, that specifically associates with TRAF6 [4].
• Our findings provide evidence that a MC159/TRAF2/TRAF3 complex regulates a new aspect of Fas signaling, and identify MC159 FLIP as a molecule that targets multiple features of Fas-induced cell death [5].
• In normal human urothelial cells, mCD40L did not trigger apoptosis, but induced rapid downregulation of TRAF2 and 3, thereby paralleling the situation in B-lymphocytes [6].
• Surprisingly, TNF-alpha stimulation potently up-regulates cxcl13 mRNA expression in wild-type murine embryonic fibroblasts, which is impaired in traf2(-/-) and relA(-/-) murine embryonic fibroblasts [7].
• Furthermore, gene ablation of TRAF2 or combined down-regulation of TRAF1 and TRAF2 did not affect c-IAP2.MALT1-stimulated signaling [8].

Biological context of TANK

• NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation [9].
• MVA infection also stimulated the expression of NF-kappaB and components of the NF-kappaB signal transduction pathway, including p50 and TRAF-interacting protein [10].
• The observed trend supported a codominant effect of the relevant haplotype of I-TRAF gene in determination of radial BMD [1].
• In genetic studies of 382 Japanese adult women, we found that genotypes of two promoter variations of I-TRAF gene, -1542T/G and -525G/C, were similarly associated with radial BMD levels [1].
• The c-IAP2.MALT1 fusion protein associates with TRAF1 and TRAF2 using the same binding site [8].

Anatomical context of TANK

• The subcellular localization of the TNF receptor-associated factor-2 (TRAF2) adaptor protein in human endothelial cells, which mediates proinflammatory responses of TNF, has been analyzed by confocal immunofluorescence microscopy and by Western blotting of fractionated cell extracts [11].
• In contrast, sTNF-alpha stimulated the expression of TRAF1 and TRAF2, recruiting both molecules onto the cell membrane poststimulation [12].
• Antigen-presenting cells in HIV pathogenesis and therapy: summary of the October 17-18, 2002, Think Tank meeting [13].
• The seventh annual Optic Nerve Rescue And Regeneration Think Tank: Immune modulation and gene expression in glaucoma [14].

Associations of TANK with chemical compounds

• Tumor necrosis factor receptor associated factor-interacting protein (I-TRAF) is an essential effecter of the tumor necrosis factor receptor-signaling cascade, one of the most potent bone-resorbing systems [1].
• The Inhibitor of Apoptosis Protein Fusion c-IAP2{middle dot}MALT1 Stimulates NF-{kappa}B Activation Independently of TRAF1 AND TRAF2 [8].
• On the basis of proteomic data, we showed that cisplatin induced TRAF2-mediated NF-kappaB downregulation [15].
• Acute Suppression of Serum IgM and IgA in Tank Workers Exposed to Benzene [16].
• Nitrate concentration in Ocean Tank at the New Jersey State Aquarium reached 9500 microM after 6 years of operation [17].

Physical interactions of TANK

• RESULTS: I-TRAF/TANK was isolated as a molecule that interacts specifically with inducible IkappaB kinase (IKK-i) by the yeast two-hybrid screening procedure [9].

Other interactions of TANK

• The NF-kappaB activation was analyzed using the electrophoresis mobility shift assay; TRAF1, TRAF2, TANK/I-TRAF, and caspase 3 expression were studied using Western blot analysis [18].
• TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain [19].
• TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation [20].
• Expressing pattern of three genes and proteins (CDK5, Bak, and I-TRAF) were matched in both analyses of cDNA microarray and proteomics [21].

Analytical, diagnostic and therapeutic context of TANK

• Three members of staff gave each Think Tank group a communal oral examination and the performance of the group was given a grade [22].

References