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Gene Review

DNER  -  delta/notch-like EGF repeat containing

Homo sapiens

Synonyms: BET, Delta and Notch-like epidermal growth factor-related receptor, UNQ26, UNQ262/PRO299, bet
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High impact information on DNER

  • In the developing cerebellum, DNER is highly expressed in Purkinje cell dendrites, which are tightly associated with radial fibers of Bergmann glia expressing Notch [1].
  • DNER protein is strongly expressed in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells, and Purkinje cells [2].
  • DNER protein is localized to the dendritic plasma membrane and endosomes and is excluded from the axons, even when overexpressed [2].
  • The tyrosine-based sorting motif in the cytoplasmic domain is required for dendritic targeting of DNER [2].
  • In vitro studies demonstrated that DNER mediates Notch signaling by cell-cell interaction [3].


  1. DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Eiraku, M., Tohgo, A., Ono, K., Kaneko, M., Fujishima, K., Hirano, T., Kengaku, M. Nat. Neurosci. (2005) [Pubmed]
  2. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. Eiraku, M., Hirata, Y., Takeshima, H., Hirano, T., Kengaku, M. J. Biol. Chem. (2002) [Pubmed]
  3. DNER as key molecule for cerebellar maturation. Saito, S.Y., Takeshima, H. Cerebellum (2006) [Pubmed]
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