Disease relevance of H4L

• Interaction between nucleoside triphosphate phosphohydrolase I and the H4L subunit of the viral RNA polymerase is required for vaccinia virus early gene transcript release [1].

High impact information on H4L

• Vaccinia virus early gene transcription is catalyzed by a multisubunit virion form of RNA polymerase that possesses a unique subunit, H4L [2].
• The H4L binding site on NPH I was mapped to the COOH-terminal region between 457 and 631 [1].
• H4L binds to the C-terminal region of J3R between amino acids 169 and 333 [3].

Other interactions of H4L

• Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase [3].

References