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Gene Review

N  -  orf18

Haemophilus phage HP2

 
 
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Disease relevance of HP2p18

  • The satellite bacteriophage P4 does not have genes coding for any major structural proteins, but assembles a capsid from the gene products of bacteriophage P2 [1].
  • These stimulated proteins include the major P2 capsid protein (N gene product) and a major component of the P2 phage tail (FII gene product) [2].
  • The capsid protein of bacteriophage P2, encoded by the N gene, can assemble into icosahedral capsids of two possible sizes, with diameters of 60 and 45 nm, respectively [3].
 

High impact information on HP2p18

References

  1. Image reconstruction from cryo-electron micrographs reveals the morphopoietic mechanism in the P2-P4 bacteriophage system. Dokland, T., Lindqvist, B.H., Fuller, S.D. EMBO J. (1992) [Pubmed]
  2. In vitro activation of bacteriophage P2 late gene expression by extracts from phage P4-infected cells. Gibbs, W., Eisen, H., Calendar, R. J. Virol. (1983) [Pubmed]
  3. Bacteriophage P2 and P4 assembly: alternative scaffolding proteins regulate capsid size. Marvik, O.J., Sharma, P., Dokland, T., Lindqvist, B.H. Virology (1994) [Pubmed]
  4. DNA knots reveal a chiral organization of DNA in phage capsids. Arsuaga, J., Vazquez, M., McGuirk, P., Trigueros, S., Sumners, d.e. .W., Roca, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
 
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