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Gene Review:

N - orf18

Haemophilus phage HP2

Arsuaga, J. et al., Marvik, O.J. et al., Dokland, T. et al., Gibbs, W. et al.

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Disease relevance of HP2p18

The satellite bacteriophage P4 does not have genes coding for any major structural proteins, but assembles a capsid from the gene products of bacteriophage P2 [1].
These stimulated proteins include the major P2 capsid protein (N gene product) and a major component of the P2 phage tail (FII gene product) [2].
The capsid protein of bacteriophage P2, encoded by the N gene, can assemble into icosahedral capsids of two possible sizes, with diameters of 60 and 45 nm, respectively [3].

High impact information on HP2p18

We recently showed that most DNA molecules extracted from bacteriophage P4 are highly knotted because of the cyclization of the linear DNA molecule confined in the phage capsid [4].

References

Image reconstruction from cryo-electron micrographs reveals the morphopoietic mechanism in the P2-P4 bacteriophage system. Dokland, T., Lindqvist, B.H., Fuller, S.D. EMBO J. (1992) [Pubmed]
In vitro activation of bacteriophage P2 late gene expression by extracts from phage P4-infected cells. Gibbs, W., Eisen, H., Calendar, R. J. Virol. (1983) [Pubmed]
Bacteriophage P2 and P4 assembly: alternative scaffolding proteins regulate capsid size. Marvik, O.J., Sharma, P., Dokland, T., Lindqvist, B.H. Virology (1994) [Pubmed]
DNA knots reveal a chiral organization of DNA in phage capsids. Arsuaga, J., Vazquez, M., McGuirk, P., Trigueros, S., Sumners, d.e. .W., Roca, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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