Disease relevance of Bacteriophage P2

• The R-type pyocin of Pseudomonas aeruginosa is related to P2 phage, and the F-type is related to lambda phage [1].
• Interaction of P2 bacteriophage with the dnaB gene of Escherichia coli [2].
• Second, antibodies against gpQ bind to the portal structure in disrupted P2 phage virions, as observed by electron microscopy [3].
• E. coli B and K-12 were found to support the growth of the ogr-defective P2 phage because of the presence of functional ogr genes located in cryptic P2-like prophages in these strains [4].

High impact information on Bacteriophage P2

• The psu gene product of "phasmid" (phage-plasmid) P4 acts as a transcription antitermination factor in trans and in cis, respectively, within the morphogenic operons of its P2 phage helper during lytic viral development and on P4 itself during the establishment stage of its alternative mode of propagation as a plasmid [5].
• These stimulated proteins include the major P2 capsid protein (N gene product) and a major component of the P2 phage tail (FII gene product) [6].
• Complementation experiments and transcriptional analysis show that a nonreplicating P2 phage expresses the ogr gene from Pogr but is unable to transcribe the late genes [7].
• This system is based upon the inhibition of translation of P2 phage repressor protein [8].

References