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Gene Review

ciaR  -  DNA-binding response regulator CiaR

Streptococcus pneumoniae R6

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Disease relevance of ciaR


High impact information on ciaR

  • To circumvent this problem, we have used microarray analysis to investigate the transition from non-competence to competence in a comC-null wild-type strain and its ciaR derivative after the addition of CSP [1].
  • The ComCDEUP transposon mutations included four independent insertions in the ciaR gene, which encodes the response regulator of a two-component system previously found to affect competence, and two immediately upstream of the comAB operon [3].
  • Determination of a 2265 bp DNA sequence of the resistance determinant revealed two open reading frames, ciaR and ciaH, whose deduced amino acid sequence identified the corresponding proteins as the response regulator and histidine kinase receptor, respectively (members of the two families of bacterial signal-transducing proteins) [4].
  • This gene is adjacent to ciaR, which encodes a DNA-binding protein involved in the regulation of genes responding to environmental signals sensed by the histidine kinase [5].

Biological context of ciaR


  1. Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells. Dagkessamanskaia, A., Moscoso, M., Hénard, V., Guiral, S., Overweg, K., Reuter, M., Martin, B., Wells, J., Claverys, J.P. Mol. Microbiol. (2004) [Pubmed]
  2. The ciaR/ciaH regulatory network of Streptococcus pneumoniae. Zähner, D., Kaminski, K., van der Linden, M., Mascher, T., Meral, M., Hakenbeck, R. J. Mol. Microbiol. Biotechnol. (2002) [Pubmed]
  3. Cross-regulation of competence pheromone production and export in the early control of transformation in Streptococcus pneumoniae. Martin, B., Prudhomme, M., Alloing, G., Granadel, C., Claverys, J.P. Mol. Microbiol. (2000) [Pubmed]
  4. A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Guenzi, E., Gasc, A.M., Sicard, M.A., Hakenbeck, R. Mol. Microbiol. (1994) [Pubmed]
  5. Genetic and physiological studies of the CiaH-CiaR two-component signal-transducing system involved in cefotaxime resistance and competence of Streptococcus pneumoniae. Giammarinaro, P., Sicard, M., Gasc, A.M. Microbiology (Reading, Engl.) (1999) [Pubmed]
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