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Gene Review:

atpE - ATP synthase F0F1 subunit C

Streptococcus pneumoniae R6

Fenoll, A. et al., Balsalobre, L. et al.

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Disease relevance of atpE

In addition, comparison of the sequence of the atpCAB genes of S. pneumoniae R6 (OptS) and M222 (an OptR strain produced by interspecies recombination between pneumococcus and S. oralis), and S. oralis revealed that, in M222, an interchange of atpC and atpA had occurred [1].

High impact information on atpE

Sequence analysis and transformation experiments showed that the atpC gene is responsible for the optochin-sensitive resistant (OptS/OptR) phenotype [1].
The determination of the partial nucleotide sequence embracing the atp operon encoding the F(o)F(1) H(+)-ATPase indicated that the optochin susceptibility of the isolates was due to the acquisition of atpC, atpA, and part of atpB from S. pneumoniae by horizontal gene transfer [2].

References

Molecular basis of the optochin-sensitive phenotype of pneumococcus: characterization of the genes encoding the F0 complex of the Streptococcus pneumoniae and Streptococcus oralis H(+)-ATPases. Fenoll, A., Muñoz, R., García, E., de la Campa, A.G. Mol. Microbiol. (1994) [Pubmed]
Molecular characterization of disease-associated streptococci of the mitis group that are optochin susceptible. Balsalobre, L., Hern??ndez-Madrid, A., Llull, D., Mart??n-Galiano, A.J., Garc??a, E., Fenoll, A., de la Campa, A.G. J. Clin. Microbiol. (2006) [Pubmed]

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