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Gene Review

atpB  -  ATP synthase F0F1 subunit A

Streptococcus pneumoniae R6

 
 
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Disease relevance of atpB

  • In addition, comparison of the sequence of the atpCAB genes of S. pneumoniae R6 (OptS) and M222 (an OptR strain produced by interspecies recombination between pneumococcus and S. oralis), and S. oralis revealed that, in M222, an interchange of atpC and atpA had occurred [1].
 

High impact information on atpB

  • Analysis of the atpCAB region, which encodes the c, a, and b subunits of the F(0)F(1) H(+)-ATPase, the target of optochin, revealed high degrees of similarity between S. mitis 1162/99 and S. pneumoniae in atpC, atpA, and the N terminus of atpB [2].
  • The determination of the partial nucleotide sequence embracing the atp operon encoding the F(o)F(1) H(+)-ATPase indicated that the optochin susceptibility of the isolates was due to the acquisition of atpC, atpA, and part of atpB from S. pneumoniae by horizontal gene transfer [3].

References

  1. Molecular basis of the optochin-sensitive phenotype of pneumococcus: characterization of the genes encoding the F0 complex of the Streptococcus pneumoniae and Streptococcus oralis H(+)-ATPases. Fenoll, A., Muñoz, R., García, E., de la Campa, A.G. Mol. Microbiol. (1994) [Pubmed]
  2. Genetic characterization of optochin-susceptible viridans group streptococci. Martín-Galiano, A.J., Balsalobre, L., Fenoll, A., de la Campa, A.G. Antimicrob. Agents Chemother. (2003) [Pubmed]
  3. Molecular characterization of disease-associated streptococci of the mitis group that are optochin susceptible. Balsalobre, L., Hern??ndez-Madrid, A., Llull, D., Mart??n-Galiano, A.J., Garc??a, E., Fenoll, A., de la Campa, A.G. J. Clin. Microbiol. (2006) [Pubmed]
 
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