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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CIAO1  -  cytosolic iron-sulfur assembly component 1

Homo sapiens

Synonyms: CIA1, WD repeat-containing protein 39, WDR39
 
 
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Disease relevance of CIAO1

  • Structural organization, tissue expression, and chromosomal localization of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1 [1].
 

High impact information on CIAO1

  • Thus, Ciao 1 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation [2].
  • Ciao 1 does not inhibit binding of WT1 to its consensus nucleotide sequence and does not affect the repression activity of WT1 [2].
  • The clustering results of the CIAO method are more significantly relevant to the biological gene annotations than those of other methods, indicating its effectiveness and potential for clustering incomplete gene expression data [3].
  • To test the performance of the CIAO, we applied the CIAO and conventional imputation-based clustering methods, e.g. k-means based on KNNimpute, for clustering two yeast incomplete data sets, and compared the clustering result of each method using the Saccharomyces Genome Database annotations [3].

References

  1. Structural organization, tissue expression, and chromosomal localization of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1. Johnstone, R.W., Tommerup, N., Hansen, C., Vissing, H., Shi, Y. Immunogenetics (1999) [Pubmed]
  2. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. Johnstone, R.W., Wang, J., Tommerup, N., Vissing, H., Roberts, T., Shi, Y. J. Biol. Chem. (1998) [Pubmed]
  3. Towards clustering of incomplete microarray data without the use of imputation. Kim, D.W., Lee, K.Y., Lee, K.H., Lee, D. Bioinformatics (2007) [Pubmed]
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