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Gene Review:

CC_0373 - smc protein

Caulobacter crescentus CB15

Jensen, R.B. et al., Jensen, R.B. et al.

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Disease relevance of CC_0373

A null mutation in the Caulobacter crescentus smc gene is conditionally lethal and causes a cell cycle arrest at the predivisional cell stage [1].

High impact information on CC_0373

The specific cell cycle arrest in the smc null mutant indicates the presence of a cell cycle checkpoint that senses perturbations in chromosome organization or segregation [1].
Thus, we propose that the Caulobacter chromosomal origins have specific cellular addresses and that the SMC protein plays important roles in maintaining chromosome structure and in partitioning [1].
Chromosome segregation in wild-type and smc null mutant cells was examined by monitoring the intracellular localization of the replication origin and terminus by using fluorescence in situ hybridization [1].
Although transcription from the smc promoter is induced during early S phase, a cell cycle transcription pattern previously observed with multiple DNA replication and repair genes, the SMC protein is present throughout the entire cell cycle [2].

References

The Caulobacter crescentus smc gene is required for cell cycle progression and chromosome segregation. Jensen, R.B., Shapiro, L. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Cell-cycle-regulated expression and subcellular localization of the Caulobacter crescentus SMC chromosome structural protein. Jensen, R.B., Shapiro, L. J. Bacteriol. (2003) [Pubmed]

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