Disease relevance of Caulobacter

• The regulatory circuitry controlling expression of the polar flagellar genes of members of the Vibrionaceae is different from the peritrichous system of enteric bacteria or the polar system of Caulobacter crescentus [1].
• We demonstrate here that the expression of the Escherichia coli chemoreceptor gene tsr, with 2.6 kilobases of its upstream sequence, is temporally controlled in Caulobacter crescentus [2].
• Two members of this group, DR1885 from Deinococcus radiodurans and CC3502 from Caulobacter crescentus, were expressed, and their interaction with copper was investigated [3].
• The nucleotide sequence of the gene, called flbA, predicted a protein of 78,864 Da, with significant homology to a group of related proteins including the Yersinia pestis LcrD, Salmonella typhimurium InvA, and Caulobacter crescentus FlbF proteins [4].
• The high degree of sequence homology of proteins derived from widely differing organisms, including Caulobacter and Yersinia species, suggests that FlbF and LcrD may be representatives of a larger family of regulatory proteins with a common sensor mechanism for modifying responses to appropriate stimuli [5].

High impact information on Caulobacter

• Here we identify an essential two-component signal transduction protein that controls multiple events in the Caulobacter cell cycle, including cell division, stalk synthesis, and cell cycle-specific transcription [6].
• CcrM, an adenine DNA methyltransferase, is essential for viability in Caulobacter crescentus [7].
• The transcription of many spatially and temporally controlled flagellar structural genes in Caulobacter requires the RNA polymerase sigma 54 subunit [8].
• Control of synthesis and positioning of a Caulobacter crescentus flagellar protein [9].
• Cell cycle progression in Caulobacter is driven by the master transcriptional regulators CtrA and GcrA [10].

Chemical compound and disease context of Caulobacter

• Visualization of the movement of single histidine kinase molecules in live Caulobacter cells [11].
• The Caulobacter crescentus divL gene encodes a novel bacterial tyrosine kinase essential for cell viability and division [12].
• Exogenous derivatives of 3':5'-cyclic GMP, 8-bromo- and N2,O2'-dibutyryl cyclic GMP, coordinately repress surface structure differentiation in Caulobacter crescentus [13].
• The contribution of proteins to the structure of the Caulobacter nucleoid has been analyzed by using polyacrylamide gel electrophoresis of proteins labeled both for short intervals and continuously throughout the cell cycle [14].
• A specific cyclic guanosine 3':5'-monophosphate-binding protein in Caulobacter crescentus [15].

Biological context of Caulobacter

• The kinetic properties of an adenine DNA methyltransferase involved in cell cycle regulation of Caulobacter crescentus have been elucidated by using defined unmethylated or hemimethylated DNA (DNAHM) substrates [16].
• Thus, we propose that the Caulobacter chromosomal origins have specific cellular addresses and that the SMC protein plays important roles in maintaining chromosome structure and in partitioning [17].
• The most recently discovered example is a remarkable histidine kinase that oscillates between polar and global distributions while temporally regulating transcription and DNA replication in Caulobacter [18].
• Caulobacter crescentus pilin. Purification, chemical characterization, and NH2-terminal amino acid sequence of a structural protein regulated during development [19].
• Cells lacking ClpB display a prolonged shutoff phase of the heat shock response in Caulobacter crescentus [20].

Anatomical context of Caulobacter

• A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus [21].
• Molecular genetics of the flgI region and its role in flagellum biosynthesis in Caulobacter crescentus [22].
• The eukaryotic SODs most closely resemble that of Caulobacter crescentus, a relatively close descendant of the mitochondrial ancestor, suggesting that sodC may have entered the eukaryotes during the establishment of mitochondria [23].
• Cytoplasmic and outer membranes of Caulobacter crescentus were separated by isopycnic sucrose gradient centrifugation into two peaks with buoyant densities 1.22 and 1.14 g/cm3 [24].

Gene context of Caulobacter

• Here we show biochemically that CC3396, a GGDEF-EAL composite protein from Caulobacter crescentus is a soluble PDE [25].
• We have identified the parC and parE genes encoding DNA topoisomerase IV (Topo IV) in Caulobacter crescentus [26].
• Requirement of topoisomerase IV parC and parE genes for cell cycle progression and developmental regulation in Caulobacter crescentus [26].
• Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle [27].
• The Caulobacter heat shock sigma factor gene rpoH is positively autoregulated from a sigma32-dependent promoter [28].

Analytical, diagnostic and therapeutic context of Caulobacter

• High-pressure liquid chromatography of a muramidase digest of murein sacculi from Caulobacter crescentus showed that the absence of D-alanine carboxypeptidase activity in the cells was reflected by a very high content of pentapeptide in the murein [29].

References