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Gene Review:

surA - peptidyl-prolyl cis-trans isomerase (PPIase)

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0054, JW0052

Justice, S.S. et al., Missiakas, D. et al., Tormo, A. et al., Dartigalongue, C. et al.

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Disease relevance of surA

surA, an Escherichia coli gene essential for survival in stationary phase [1].

High impact information on surA

The combination of ppiD and surA null mutations is lethal [2].
Using multicopy libraries, we cloned two genes, surA and fkpA, that decreased the sigma E-dependent response constitutively induced by misfolded proteins [3].
Complementation of UTI89 surA::kan with a plasmid (pDH15) containing surA under the control of an arabinose-inducible promoter restored in vivo binding and invasion events [4].
Invasion into bladder epithelial cells was disproportionately reduced when surA was genetically disrupted in the UPEC strain UTI89, demonstrating that binding alone is not sufficient for invasion [4].

References

surA, an Escherichia coli gene essential for survival in stationary phase. Tormo, A., Almirón, M., Kolter, R. J. Bacteriol. (1990) [Pubmed]
A new heat-shock gene, ppiD, encodes a peptidyl-prolyl isomerase required for folding of outer membrane proteins in Escherichia coli. Dartigalongue, C., Raina, S. EMBO J. (1998) [Pubmed]
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH. Missiakas, D., Betton, J.M., Raina, S. Mol. Microbiol. (1996) [Pubmed]
Maturation of intracellular Escherichia coli communities requires SurA. Justice, S.S., Lauer, S.R., Hultgren, S.J., Hunstad, D.A. Infect. Immun. (2006) [Pubmed]

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