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Gene Review

fkpA  -  FKBP-type peptidyl-prolyl cis-trans...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3334, JW3309, yzzS
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Disease relevance of fkpA


High impact information on fkpA

  • Using multicopy libraries, we cloned two genes, surA and fkpA, that decreased the sigma E-dependent response constitutively induced by misfolded proteins [3].
  • Because Mip proteins enhance the ability of these intracellular pathogens to survive within macrophages and epithelial cells, we tested whether the product of the fkpA gene would have the same effect on the intracellular growth of a virulent strain of S. typhimurium [1].
  • Overexpression of FkpA or deletion of fkpA from the E. coli chromosome had no detrimental effect on bacterial growth, indicating that fkpA is not an essential gene [2].


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