Disease relevance of fkpA

• Complementation of the fkpA mutation by a plasmid-borne wild-type fkpA gene from E. coli restored the ability of S. typhimurium KY32H1 to grow normally in J774.A1 cells [1].
• Decreased intracellular survival of an fkpA mutant of Salmonella typhimurium Copenhagen [1].
• Hybridization of fkpA-specific DNA probes to genomic blots revealed that similar genes exist in several representatives of the Enterobacteriaceae [2].
• A newly identified gene in Escherichia coli, fkpA, encodes a protein with extensive similarity to the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Chlamydia trachomatis [2].

High impact information on fkpA

• Using multicopy libraries, we cloned two genes, surA and fkpA, that decreased the sigma E-dependent response constitutively induced by misfolded proteins [3].
• Because Mip proteins enhance the ability of these intracellular pathogens to survive within macrophages and epithelial cells, we tested whether the product of the fkpA gene would have the same effect on the intracellular growth of a virulent strain of S. typhimurium [1].
• Overexpression of FkpA or deletion of fkpA from the E. coli chromosome had no detrimental effect on bacterial growth, indicating that fkpA is not an essential gene [2].

References