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Gene Review: 

pyrH  -  uridylate kinase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0170, JW0166, smbA, umk
 
 
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Disease relevance of pyrH

  • The pyrH gene, encoding UMP-kinase from Escherichia coli, was cloned using as a genetic probe the property of the carAB operon to be controlled for its expression by the concentration of cytoplasmic UTP [1].
 

High impact information on pyrH

  • The open reading frame of the pyrH gene of 723 bp was found to be identical to that of the smbA gene [Yamanaka, K., et al. (1992) J. Bacteriol. 174, 7517-7526], previously described as being involved in chromosome partitioning in E. coli [1].
  • Identification and characterization of the smbA gene, a suppressor of the mukB null mutant of Escherichia coli [2].
  • The smbA gene is essential for cell proliferation in the range from 22 to 42 degrees C. Cells which lacked the SmbA protein ceased macromolecular synthesis [2].
  • The smbA mutants are sensitive to a detergent, sodium dodecyl sulfate, and they show a novel morphological phenotype under nonpermissive conditions, suggesting a defect in specific membrane sites [2].
  • Expression of the smbA gene is essential for cell growth [3].

References

  1. Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP. Serina, L., Blondin, C., Krin, E., Sismeiro, O., Danchin, A., Sakamoto, H., Gilles, A.M., Bârzu, O. Biochemistry (1995) [Pubmed]
  2. Identification and characterization of the smbA gene, a suppressor of the mukB null mutant of Escherichia coli. Yamanaka, K., Ogura, T., Niki, H., Hiraga, S. J. Bacteriol. (1992) [Pubmed]
  3. Multicopy suppressors, mssA and mssB, of an smbA mutation of Escherichia coli. Yamanaka, K., Ogura, T., Koonin, E.V., Niki, H., Hiraga, S. Mol. Gen. Genet. (1994) [Pubmed]
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