Disease relevance of ompT

• Complete nucleotide sequence and deduced amino acid sequence of the ompT gene of Escherichia coli K-12 [1].

High impact information on ompT

• Accordingly, we show that the presence of an F' episome results in increased resistance to the antimicrobial peptide protamine both in ompT mutants and in wild-type E. coli cells [2].
• Location of the ompT gene relative to that of appY on the physical map of the Escherichia coli chromosome [3].
• Results concerning the precise location of the ompT gene (encoding the outer membrane protease OmpT) on the Escherichia coli chromosome were obtained which disagree with published restriction sites in the gene [3].
• After fusion to pelB, dsbA or ompT signal peptides no recombinant product could be obtained in the periplasm using the T7 promoter [4].
• Similarly, extracts from degP- and ompT-deleted mutants were able to significantly stabilize in vitro-synthesized PLD, which otherwise disappeared within 30 min [5].

Biological context of ompT

• This effect was abolished by plasmids carrying ompT [6].

References