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Gene Review:

sucD - succinyl-CoA synthetase, NAD(P)-binding,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0717, JW0718

Buck, D. et al., Buck, D. et al., Nicholls, D.J. et al., Buck, D. et al.

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Disease relevance of sucD

The succinyl-CoA synthetase of Escherichia coli is encoded by two genes, sucC (beta subunit) and sucD (alpha subunit), which are distal genes in the sucABCD operon [1].
Cloning and nucleotide sequences of the mdh and sucD genes from Thermus aquaticus B [2].

High impact information on sucD

The sucD gene comprises 864 base pairs (288 codons, excluding the start and stop codons), and it encodes a product of Mr 29 644, corresponding to the alpha subunit of succinyl-CoA synthetase [3].
A proximal open reading frame, identified as the sucD gene, and the mdh gene may be parts of the same operon in T. aquaticus B [2].

Biological context of sucD

The succinyl-CoA synthetase activities of strains harbouring plasmids containing the sucC and sucD genes were amplified some fourfold [4].
The primary structure of the succinyl-CoA synthetase of Escherichia coli has been deduced from the nucleotide sequence of a 2451-base-pair segment of DNA containing the corresponding sucC (beta subunit) and sucD (alpha subunit) genes [3].

Associations of sucD with chemical compounds

The newly defined genes express polypeptides of 41 kDa (sucC) and 31 kDa (sucD), corresponding to the beta and alpha subunits of succinyl-CoA synthetase, respectively [4].

References

Overexpression and site-directed mutagenesis of the succinyl-CoA synthetase of Escherichia coli and nucleotide sequence of a gene (g30) that is adjacent to the suc operon. Buck, D., Guest, J.R. Biochem. J. (1989) [Pubmed]
Cloning and nucleotide sequences of the mdh and sucD genes from Thermus aquaticus B. Nicholls, D.J., Sundaram, T.K., Atkinson, T., Minton, N.P. FEMS Microbiol. Lett. (1990) [Pubmed]
Primary structure of the succinyl-CoA synthetase of Escherichia coli. Buck, D., Spencer, M.E., Guest, J.R. Biochemistry (1985) [Pubmed]
Cloning and expression of the succinyl-CoA synthetase genes of Escherichia coli K12. Buck, D., Spencer, M.E., Guest, J.R. J. Gen. Microbiol. (1986) [Pubmed]

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