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Chemical Compound Review

KST-1B6326     3-[2-[3-[[4-[[[5-(6- aminopurin-9-yl)-4...

Synonyms: AC1L1AQZ, AC1Q5VSY, AR-1B9381
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Disease relevance of succ-S-CoA


High impact information on succ-S-CoA


Chemical compound and disease context of succ-S-CoA


Biological context of succ-S-CoA


Anatomical context of succ-S-CoA


Associations of succ-S-CoA with other chemical compounds


Gene context of succ-S-CoA

  • The newly defined genes express polypeptides of 41 kDa (sucC) and 31 kDa (sucD), corresponding to the beta and alpha subunits of succinyl-CoA synthetase, respectively [24].
  • The genes encoding both subunits of the succinyl-CoA synthetase of Escherichia coli have been identified as distal genes of the suc operon, which also encodes the dehydrogenase (Elo; sucA) and succinyltransferase (E2o; sucB) components of the 2-oxoglutarate dehydrogenase complex [24].
  • The primary structure of the succinyl-CoA synthetase of Escherichia coli has been deduced from the nucleotide sequence of a 2451-base-pair segment of DNA containing the corresponding sucC (beta subunit) and sucD (alpha subunit) genes [25].
  • Two of these genes have recently been further characterized: YGR241c (YAP1802) encodes a yeast adaptor protein and YGR244c (LSC2) encodes the beta-subunit of the succinyl-CoA ligase [26].
  • Expression of hypoxic/anaerobic genes was elevated in alpha-ketoglutarate dehydrogenase mutants, whereas expression of oxidative genes was diminished, consistent with a heme signaling defect caused by inadequate levels of the heme precursor, succinyl-CoA [27].

Analytical, diagnostic and therapeutic context of succ-S-CoA


  1. Cloning and sequencing of the cytoplasmic precursor to the alpha subunit of rat liver mitochondrial succinyl-CoA synthetase. Henning, W.D., Upton, C., McFadden, G., Majumdar, R., Bridger, W.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  2. Characterization of nucleoside-diphosphate kinase from Pseudomonas aeruginosa: complex formation with succinyl-CoA synthetase. Kavanaugh-Black, A., Connolly, D.M., Chugani, S.A., Chakrabarty, A.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Regulation of D-beta-hydroxybutyrate dehydrogenase in rat hepatoma cell lines. Zhang, W.W., Churchill, S., Lindahl, R., Churchill, P. Cancer Res. (1989) [Pubmed]
  4. Evolutionarily homologous alpha 2 beta 2 oligomeric structures in beta-ketoadipate succinyl-CoA transferases from Acinetobacter calcoaceticus and Pseudomonas putida. Yeh, W.K., Ornston, L.N. J. Biol. Chem. (1981) [Pubmed]
  5. Quaternary structure of delta-aminolevulinic acid synthase from Rhodopseudomonas spheroides. Nandi, D.L., Shemin, D. J. Biol. Chem. (1977) [Pubmed]
  6. Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion. Elpeleg, O., Miller, C., Hershkovitz, E., Bitner-Glindzicz, M., Bondi-Rubinstein, G., Rahman, S., Pagnamenta, A., Eshhar, S., Saada, A. Am. J. Hum. Genet. (2005) [Pubmed]
  7. Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes. Riddle, R.D., Yamamoto, M., Engel, J.D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. Expression and kinetic characterization of methylmalonyl-CoA mutase from patients with the mut- phenotype: evidence for naturally occurring interallelic complementation. Janata, J., Kogekar, N., Fenton, W.A. Hum. Mol. Genet. (1997) [Pubmed]
  9. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. Westin, M.A., Hunt, M.C., Alexson, S.E. J. Biol. Chem. (2005) [Pubmed]
  10. MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation. Korotkova, N., Lidstrom, M.E. J. Biol. Chem. (2004) [Pubmed]
  11. Affinity labeling of succinyl-CoA synthetase from porcine heart and Escherichia coli with oxidized coenzyme A disulfide. Collier, G.E., Nishimura, J.S. J. Biol. Chem. (1978) [Pubmed]
  12. Adenosine 5'-O-(3-thio)triphosphate, a substrate and potent inhibitor of Escherichia coli succinyl-CoA synthetase. Additional evidence for a cooperative alternating-sites mechanism. Nishimura, J.S., Mitchell, T. J. Biol. Chem. (1984) [Pubmed]
  13. Site-directed mutagenesis of Escherichia coli succinyl-CoA synthetase. Histidine 142 alpha is a facilitative catalytic residue. Luo, G.X., Nishimura, J.S. J. Biol. Chem. (1991) [Pubmed]
  14. Crystallization of succinyl-CoA synthetase from Escherichia coli. Wolodko, W.T., James, M.N., Bridger, W.A. J. Biol. Chem. (1984) [Pubmed]
  15. Escherichia coli succinyl coenzyme A synthetase. Inhibition of ATP-stimulated succinate----succinyl coenzyme A exchange at low succinyl coenzyme A concentrations by an ADP trap. Nishimura, J.S., Mitchell, T. J. Biol. Chem. (1984) [Pubmed]
  16. Mitochondrial substrate level phosphorylation is essential for growth of procyclic Trypanosoma brucei. Bochud-Allemann, N., Schneider, A. J. Biol. Chem. (2002) [Pubmed]
  17. The succinate mechanism of insulin release. Fahien, L.A., MacDonald, M.J. Diabetes (2002) [Pubmed]
  18. Binding of the enzymes of fatty acid beta-oxidation and some related enzymes to pig heart inner mitochondrial membrane. Sumegi, B., Srere, P.A. J. Biol. Chem. (1984) [Pubmed]
  19. Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion. Kowluru, A. Diabetologia (2001) [Pubmed]
  20. Active enzyme sedimentation, sedimentation velocity, and sedimentation equilibrium studies of succinyl-CoA synthetases of porcine heart and Escherichia coli. Wolodko, W.T., Kay, C.M., Bridger, W.A. Biochemistry (1986) [Pubmed]
  21. Enzyme-to-enzyme channelling of Krebs cycle metabolic intermediates in Caco-2 cells exposed to [2-13c]propionate. Malaisse, W.J., Zhang, T.M., Verbruggen, I., Willem, R. Biochem. J. (1996) [Pubmed]
  22. Catalysis of a step of the overall reaction by the alpha subunit of Escherichia coli succinyl coenzyme A synthetase. Pearson, P.H., Bridger, W.A. J. Biol. Chem. (1975) [Pubmed]
  23. Pre-steady-state reaction of 5-aminolevulinate synthase. Evidence for a rate-determining product release. Hunter, G.A., Ferreira, G.C. J. Biol. Chem. (1999) [Pubmed]
  24. Cloning and expression of the succinyl-CoA synthetase genes of Escherichia coli K12. Buck, D., Spencer, M.E., Guest, J.R. J. Gen. Microbiol. (1986) [Pubmed]
  25. Primary structure of the succinyl-CoA synthetase of Escherichia coli. Buck, D., Spencer, M.E., Guest, J.R. Biochemistry (1985) [Pubmed]
  26. Disruption and phenotypic analysis of six open reading frames from chromosome VII of Saccharomyces cerevisiae reveals one essential gene. Guerreiro, P., Rodrigues-Pousada, C. Yeast (2001) [Pubmed]
  27. Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. McCammon, M.T., Epstein, C.B., Przybyla-Zawislak, B., McAlister-Henn, L., Butow, R.A. Mol. Biol. Cell (2003) [Pubmed]
  28. Affinity chromatography and affinity labeling of rat liver succinyl-CoA synthetase. Ball, D.J., Nishimura, J.S. J. Biol. Chem. (1980) [Pubmed]
  29. Isolation of the alpha and beta subunits of Escherichia coli succinyl coenzyme A synthetase and their recombination into active enzyme. Pearson, P.H., Bridger, W.A. J. Biol. Chem. (1975) [Pubmed]
  30. Native-like intermediate on the folding pathway of Escherichia coli succinyl-CoA synthetase. Khan, I.A., Nishimura, J.S. J. Biol. Chem. (1988) [Pubmed]
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