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Gene Review

mdh  -  malate dehydrogenase, NAD(P)-binding

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3225, JW3205
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Disease relevance of mdh


High impact information on mdh


Chemical compound and disease context of mdh


Biological context of mdh


Anatomical context of mdh

  • The malate dehydrogenase isozyme MDH3 of Saccharomyces cerevisiae was found to be localized to peroxisomes by cellular fractionation and density gradient centrifugation [16].
  • The MDHs purified to homogeneity from the high-expression clones were identical with the MDH isolated from T. aquaticus B cells with respect to all measured parameters [17].
  • Adsorption of pre-purified human serum albumin (HSA) and malate dehydrogenase (MDH) displayed highest maximum binding capacities on HEC-coated dye-ligand-affinity membranes, ranging from (163 micrograms/cm2 for HSA to 316 micrograms/cm2 for MDH [18].

Associations of mdh with chemical compounds


Other interactions of mdh


Analytical, diagnostic and therapeutic context of mdh


  1. Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica. Boyd, E.F., Nelson, K., Wang, F.S., Whittam, T.S., Selander, R.K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Cloning and nucleotide sequences of the mdh and sucD genes from Thermus aquaticus B. Nicholls, D.J., Sundaram, T.K., Atkinson, T., Minton, N.P. FEMS Microbiol. Lett. (1990) [Pubmed]
  3. Purification and properties of malate dehydrogenase from Pseudomonas testosteroni. You, K.S., Kaplan, N.O. J. Bacteriol. (1975) [Pubmed]
  4. Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase. Kather, B., Stingl, K., van der Rest, M.E., Altendorf, K., Molenaar, D. J. Bacteriol. (2000) [Pubmed]
  5. The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline. Muramatsu, H., Mihara, H., Kakutani, R., Yasuda, M., Ueda, M., Kurihara, T., Esaki, N. J. Biol. Chem. (2005) [Pubmed]
  6. Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation. Figueiredo, L., Klunker, D., Ang, D., Naylor, D.J., Kerner, M.J., Georgopoulos, C., Hartl, F.U., Hayer-Hartl, M. J. Biol. Chem. (2004) [Pubmed]
  7. Structural analyses of a malate dehydrogenase with a variable active site. Bell, J.K., Yennawar, H.P., Wright, S.K., Thompson, J.R., Viola, R.E., Banaszak, L.J. J. Biol. Chem. (2001) [Pubmed]
  8. Cloning and sequence of the mdh structural gene of Escherichia coli coding for malate dehydrogenase. Vogel, R.F., Entian, K.D., Mecke, D. Arch. Microbiol. (1987) [Pubmed]
  9. Crystal structure of Escherichia coli malate dehydrogenase. A complex of the apoenzyme and citrate at 1.87 A resolution. Hall, M.D., Levitt, D.G., Banaszak, L.J. J. Mol. Biol. (1992) [Pubmed]
  10. An operon encoding aspartokinase and purine phosphoribosyltransferase in Thermus flavus. Nishiyama, M., Kukimoto, M., Beppu, T., Horinouchi, S. Microbiology (Reading, Engl.) (1995) [Pubmed]
  11. The mannitol dehydrogenase gene (mdh) from Leuconostoc mesenteroides is distinct from other known bacterial mdh genes. Aarnikunnas, J., Rönnholm, K., Palva, A. Appl. Microbiol. Biotechnol. (2002) [Pubmed]
  12. Mechanistic studies on malate dehydrogenase from Escherichia coli. Wright, S.K., Zhao, F.J., Rardin, J., Milbrandt, J., Helton, M., Furumo, N.C. Arch. Biochem. Biophys. (1995) [Pubmed]
  13. Effect of ozone on metabolic activities of Escherichia coli K-12. Komanapalli, I.R., Mudd, J.B., Lau, B.H. Toxicol. Lett. (1997) [Pubmed]
  14. Complete sequence of the Salmonella typhimurium gene encoding malate dehydrogenase. Lu, C.D., Abdelal, A.T. Gene (1993) [Pubmed]
  15. Isolation and expression of the Escherichia coli gene encoding malate dehydrogenase. Sutherland, P., McAlister-Henn, L. J. Bacteriol. (1985) [Pubmed]
  16. Expression and function of a mislocalized form of peroxisomal malate dehydrogenase (MDH3) in yeast. McAlister-Henn, L., Steffan, J.S., Minard, K.I., Anderson, S.L. J. Biol. Chem. (1995) [Pubmed]
  17. Overexpression of the Thermus aquaticus B malate dehydrogenase-encoding gene in Escherichia coli. Alldread, R.M., Nicholls, D.J., Sundaram, T.K., Scawen, M.D., Atkinson, T. Gene (1992) [Pubmed]
  18. A study of combined filtration and adsorption on nylon-based dye-affinity membranes: separation of recombinant L-alanine dehydrogenase from crude fermentation broth. Weissenborn, M., Hutter, B., Singh, M., Beeskow, T.C., Anspach, F.B. Biotechnol. Appl. Biochem. (1997) [Pubmed]
  19. Crystal structure of a ternary complex of Escherichia coli malate dehydrogenase citrate and NAD at 1.9 A resolution. Hall, M.D., Banaszak, L.J. J. Mol. Biol. (1993) [Pubmed]
  20. Cloning, expression, and sequence analysis of the Bacillus methanolicus C1 methanol dehydrogenase gene. de Vries, G.E., Arfman, N., Terpstra, P., Dijkhuizen, L. J. Bacteriol. (1992) [Pubmed]
  21. Multichannel reverse transcription-polymerase chain reaction microdevice for rapid gene expression and biomarker analysis. Toriello, N.M., Liu, C.N., Mathies, R.A. Anal. Chem. (2006) [Pubmed]
  22. Effect of anaesthetics and dichlorodifluoromethane on the viability of the cells of Escherichia coli and the activities of some of its enzymes. Laverty, D.M., Fennema, O. Microbios (1985) [Pubmed]
  23. PCR primers designed from malic acid dehydrogenase gene and their use for detection of Escherichia coli in water and milk samples. Hsu, S.C., Tsen, H.Y. Int. J. Food Microbiol. (2001) [Pubmed]
  24. Location of a folding protein and shape changes in GroEL-GroES complexes imaged by cryo-electron microscopy. Chen, S., Roseman, A.M., Hunter, A.S., Wood, S.P., Burston, S.G., Ranson, N.A., Clarke, A.R., Saibil, H.R. Nature (1994) [Pubmed]
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