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Gene Review:

betA - choline dehydrogenase, a flavoprotein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0309, JW0303

Pocard, J.A. et al., Quan, R. et al.

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Disease relevance of betA

The deduced sequence of the sinorhizobial CDH protein shares only 21% identical residues with choline oxidase from Arthrobacter globiformis [1].
An elite maize inbred line DH4866 was transformed with the betA gene from Escherichia coli encoding choline dehydrogenase (EC 1.1.99.1), a key enzyme in the biosynthesis of glycine betaine from choline [2].

High impact information on betA

The mutant was deficient in choline dehydrogenase (CDH) activity, failed to oxidize [methyl-14C]choline to [methyl-14C]betaine, and did not use choline, but still used betaine, as an osmoprotectant [1].

References

Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34. Pocard, J.A., Vincent, N., Boncompagni, E., Smith, L.T., Poggi, M.C., Le Rudulier, D. Microbiology (Reading, Engl.) (1997) [Pubmed]
Engineering of enhanced glycine betaine synthesis improves drought tolerance in maize. Quan, R., Shang, M., Zhang, H., Zhao, Y., Zhang, J. Plant Biotechnol. J. (2004) [Pubmed]

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