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MeSH Review


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Disease relevance of Arthrobacter

  • Rhesus rotavirus growth in Hep G2 cells displayed trypsin-enhanced infectivity and was inhibited by pretreatment of cells with Arthrobacter ureafaciens neuraminidase but not with neuraminidase from Clostridium perfringens [1].
  • Two NAD+-dependent, highly specific pyridine-5-aldehyde dehydrogenases, 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid (Compound 1) dehydrogenase and isopyridoxal dehydrogenase, were purified to homogeneity from Pseudomonas MA-1 and Arthrobacter Cr-7, respectively [2].
  • The overall fold of PH999 is similar to that of N-carbamoylsarcosine amidohydrolase (CSHase) of Arthrobacter sp. and YcaC of Escherichia coli, a protein with unknown physiological function [3].
  • In spite of the axially orientated hydroxy group at C-4, the benzyl alpha-glycoside of N-acetyl-4-epi-D-neuraminic acid (4-epi-NeuAc) is a substrate for sialidases from Vibrio cholerae, Clostridium perfringens, and Arthrobacter ureafaciens, although to an extent which differs depending on the enzyme [4].
  • The ability of these siderophores to stimulate the growth of Salmonella typhimurium LT-2 enb-7 (a mutant deficient in the biosynthesis of enterochelin) and Arthrobacter flavescens JG-9 (a hydroxamate auxotroph) supported the conclusion that V. vulnificus produces both hydroxamate- and phenolate-type siderophores [5].

High impact information on Arthrobacter

  • Here we report crystal structures of dimethylglycine oxidase (DMGO) from the bacterium Arthrobacter globiformis, a bifunctional enzyme that catalyzes the oxidation of N,N-dimethyl glycine and the formation of 5,10-methylene tetrahydrofolate [6].
  • Molecular wires comprising a Ru(II)- or Re(I)-complex head group, an aromatic tail group, and an alkane linker reversibly inhibit the activity of the copper amine oxidase from Arthrobacter globiformis (AGAO), with K(i) values between 6 muM and 37 nM [7].
  • The N-substituted formamide-degrading microorganism was identified as Arthrobacter pascens [8].
  • The locations of Met-87, Thr-89, Val-134, and Glu-180, which contact the C-6-OH group of the substrate in the sorbitol-bound xylose isomerase from Arthrobacter [Collyer, C.A., Henrick, K. & Blow, D. M. (1990) J. Mol. Biol. 212, 211-235], are equivalent to those of Trp-139, Thr-141, Val-186, and Glu-232 in the thermophilic enzyme [9].
  • Antitumor effects of an antiangiogenic polysaccharide from an Arthrobacter species with or without a steroid [10].

Chemical compound and disease context of Arthrobacter

  • A sulfated polysaccharide-peptidoglycan complex, DS-4152, isolated from the culture supernatant of an Arthrobacter species inhibited angiogenesis and tumor growth and enhanced the antiangiogenic activity of 11 steroid hormones by 2 to 100 times [10].
  • A glucodextranase (iGDase) from Arthrobacter globiformis I42 hydrolyzes alpha-1,6-glucosidic linkages of dextran from the non-reducing end to produce beta-D-glucose via an inverting reaction mechanism and classified into the glycoside hydrolase family 15 (GH15) [11].
  • Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate: characterization and functional expression of the quinaldine 4-oxidase qoxLMS genes [12].
  • The gene coding for histamine oxidase has been cloned and sequenced from a Coryneform bacterium Arthrobacter globiformis [13].
  • The overall fold of T-protein is similar to that of the C-terminal tetrahydrofolate-binding region (residues 421-830) of Arthrobacter globiformis dimethylglycine oxidase [14].

Biological context of Arthrobacter


Anatomical context of Arthrobacter


Gene context of Arthrobacter


Analytical, diagnostic and therapeutic context of Arthrobacter


  1. Growth of group A rotaviruses in a human liver cell line. Schwarz, K.B., Moore, T.J., Willoughby, R.E., Wee, S.B., Vonderfecht, S.L., Yolken, R.H. Hepatology (1990) [Pubmed]
  2. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. Lee, Y.C., Nelson, M.J., Snell, E.E. J. Biol. Chem. (1986) [Pubmed]
  3. Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii. Du, X., Wang, W., Kim, R., Yakota, H., Nguyen, H., Kim, S.H. Biochemistry (2001) [Pubmed]
  4. Interaction of N-acetyl-4-epi-D-neuraminic acid with key enzymes of sialic acid metabolism. Gross, H.J., Kovac, A., Rose, U., Watzlawick, H., Brossmer, R. Biochemistry (1988) [Pubmed]
  5. Siderophore production by Vibrio vulnificus. Simpson, L.M., Oliver, J.D. Infect. Immun. (1983) [Pubmed]
  6. Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase. Leys, D., Basran, J., Scrutton, N.S. EMBO J. (2003) [Pubmed]
  7. Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires. Contakes, S.M., Juda, G.A., Langley, D.B., Halpern-Manners, N.W., Duff, A.P., Dunn, A.R., Gray, H.B., Dooley, D.M., Guss, J.M., Freeman, H.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning. Fukatsu, H., Hashimoto, Y., Goda, M., Higashibata, H., Kobayashi, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Switching substrate preference of thermophilic xylose isomerase from D-xylose to D-glucose by redesigning the substrate binding pocket. Meng, M., Lee, C., Bagdasarian, M., Zeikus, J.G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Antitumor effects of an antiangiogenic polysaccharide from an Arthrobacter species with or without a steroid. Tanaka, N.G., Sakamoto, N., Inoue, K., Korenaga, H., Kadoya, S., Ogawa, H., Osada, Y. Cancer Res. (1989) [Pubmed]
  11. Structural insights into substrate specificity and function of glucodextranase. Mizuno, M., Tonozuka, T., Suzuki, S., Uotsu-Tomita, R., Kamitori, S., Nishikawa, A., Sakano, Y. J. Biol. Chem. (2004) [Pubmed]
  12. Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate: characterization and functional expression of the quinaldine 4-oxidase qoxLMS genes. Parschat, K., Hauer, B., Kappl, R., Kraft, R., Huttermann, J., Fetzner, S. J. Biol. Chem. (2003) [Pubmed]
  13. Copper/topa quinone-containing histamine oxidase from Arthrobacter globiformis. Molecular cloning and sequencing, overproduction of precursor enzyme, and generation of topa quinone cofactor. Choi, Y.H., Matsuzaki, R., Fukui, T., Shimizu, E., Yorifuji, T., Sato, H., Ozaki, Y., Tanizawa, K. J. Biol. Chem. (1995) [Pubmed]
  14. Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. Lee, H.H., Kim, d.o. .J., Ahn, H.J., Ha, J.Y., Suh, S.W. J. Biol. Chem. (2004) [Pubmed]
  15. Role of copper ion in bacterial copper amine oxidase: spectroscopic and crystallographic studies of metal-substituted enzymes. Kishishita, S., Okajima, T., Kim, M., Yamaguchi, H., Hirota, S., Suzuki, S., Kuroda, S., Tanizawa, K., Mure, M. J. Am. Chem. Soc. (2003) [Pubmed]
  16. Arthrobacter D-xylose isomerase: partial proteolysis with thermolysin. Siddiqui, K.S., Rangarajan, M., Hartley, B.S., Kitmitto, A., Panico, M., Blench, I.P., Morris, H.R. Biochem. J. (1993) [Pubmed]
  17. Simultaneous horizontal gene transfer of a gene coding for ribosomal protein l27 and operational genes in Arthrobacter sp. Garcia-Vallvé, S., Simó, F.X., Montero, M.A., Arola, L., Romeu, A. J. Mol. Evol. (2002) [Pubmed]
  18. Oxidative side-chain and ring fission of pregnanes by Arthrobacter simplex. Mahato, S.B., Banerjee, S., Podder, S. Biochem. J. (1988) [Pubmed]
  19. Sequence of the 165-kilobase catabolic plasmid pAO1 from Arthrobacter nicotinovorans and identification of a pAO1-dependent nicotine uptake system. Igloi, G.L., Brandsch, R. J. Bacteriol. (2003) [Pubmed]
  20. Isolation of Arthrobacter spp. from clinical specimens and description of Arthrobacter cumminsii sp. nov. and Arthrobacter woluwensis sp. nov. Funke, G., Hutson, R.A., Bernard, K.A., Pfyffer, G.E., Wauters, G., Collins, M.D. J. Clin. Microbiol. (1996) [Pubmed]
  21. Characterization of the methylenediphosphonate transport system in Arthrobacter sp. GLP-1 using the novel tritium-labelled derivative. Yakovleva, G.M., Blackburn, G.M. FEBS Lett. (1993) [Pubmed]
  22. Transformation of microcrystalline hydrocortisone by free and immobilized cells of Arthrobacter simplex. Vlahov, R., Pramatarova, V., Spassov, G., Suchodolskaya, G.V., Koshcheenko, K.A. Appl. Microbiol. Biotechnol. (1990) [Pubmed]
  23. Interaction between rat peritoneal macrophages and sialidase-treated erythrocytes: biochemical and morphological studies. Schauer, R., Schröder, C., Müller, E., von Gaudecker, B. Biomed. Biochim. Acta (1984) [Pubmed]
  24. Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor. Murata, T., Ishibashi, T., Yoshikawa, H., Khalil, A., Inomata, H. Ophthalmic Res. (1995) [Pubmed]
  25. Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34. Pocard, J.A., Vincent, N., Boncompagni, E., Smith, L.T., Poggi, M.C., Le Rudulier, D. Microbiology (Reading, Engl.) (1997) [Pubmed]
  26. A pAO1-encoded molybdopterin cofactor gene (moaA) of Arthrobacter nicotinovorans: characterization and site-directed mutagenesis of the encoded protein. Menéndez, C., Igloi, G., Henninger, H., Brandsch, R. Arch. Microbiol. (1995) [Pubmed]
  27. Methylamine oxidase from Arthrobacter P1 as a prototype of eukaryotic plasma amine oxidase and diamine oxidase. McIntire, W.S., Dooley, D.M., McGuirl, M.A., Cote, C.E., Bates, J.L. J. Neural Transm. Suppl. (1990) [Pubmed]
  28. Cloning, sequence analysis, and purification of choline oxidase from Arthrobacter globiformis: a bacterial enzyme involved in osmotic stress tolerance. Fan, F., Ghanem, M., Gadda, G. Arch. Biochem. Biophys. (2004) [Pubmed]
  29. Molecular cloning of a light-inducible gene (lipA) encoding a novel pilin from Arthrobacter photogonimos. Yang, H.S., Hoober, J.K. FEMS Microbiol. Lett. (1998) [Pubmed]
  30. A novel metal-activated pyridoxal enzyme with a unique primary structure, low specificity D-threonine aldolase from Arthrobacter sp. Strain DK-38. Molecular cloning and cofactor characterization. Liu, J.Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S., Yamada, H. J. Biol. Chem. (1998) [Pubmed]
  31. Biosynthesis of a nonphysiological sialic acid in different rat organs, using N-propanoyl-D-hexosamines as precursors. Kayser, H., Zeitler, R., Kannicht, C., Grunow, D., Nuck, R., Reutter, W. J. Biol. Chem. (1992) [Pubmed]
  32. Glycosaminoglycans in cortical autopsy samples from Alzheimer brain. Jenkins, H.G., Bachelard, H.S. J. Neurochem. (1988) [Pubmed]
  33. Analysis of interaction between the Arthrobacter sarcosine oxidase and the coenzyme flavin adenine dinucleotide by site-directed mutagenesis. Nishiya, Y., Imanaka, T. Appl. Environ. Microbiol. (1996) [Pubmed]
  34. Characterization of 1-chlorohexane halidohydrolase, a dehalogenase of wide substrate range from an Arthrobacter sp. Scholtz, R., Leisinger, T., Suter, F., Cook, A.M. J. Bacteriol. (1987) [Pubmed]
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