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Gene Review:

narJ - molybdenum-cofactor-assembly chaperone...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1220, JW1217

Dubourdieu, M. et al., Palmer, T. et al., Liu, X. et al., Blasco, F. et al.

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Disease relevance of narJ

Involvement of the narJ or narW gene product in the formation of active nitrate reductase in Escherichia coli [1].

High impact information on narJ

The cytosolic alphabeta complex accumulated in a narJ insertion mutant was rapidly degraded after induction, but was stabilized by NarJ expressed from a multicopy plasmid [2].
The narJ protein is not a component of mature nitrate reductase but narJ mutants cannot express active nitrate reductase A. Extracts from narJ strains are unable to support the in vitro activation of purified mob nitrate reductase: they lack factor X activity [3].
The narJ gene product is required for biogenesis of respiratory nitrate reductase in Escherichia coli [4].
To test this latter hypothesis, the narJ gene was disrupted in a plasmid which contained the complete narGHJI operon, and the operon was expressed in a narG::Tn10 insertion mutant [4].

References

Involvement of the narJ or narW gene product in the formation of active nitrate reductase in Escherichia coli. Blasco, F., Pommier, J., Augier, V., Chippaux, M., Giordano, G. Mol. Microbiol. (1992) [Pubmed]
Characterization of NarJ, a system-specific chaperone required for nitrate reductase biogenesis in Escherichia coli. Liu, X., DeMoss, J.A. J. Biol. Chem. (1997) [Pubmed]
Involvement of the narJ and mob gene products in distinct steps in the biosynthesis of the molybdoenzyme nitrate reductase in Escherichia coli. Palmer, T., Santini, C.L., Iobbi-Nivol, C., Eaves, D.J., Boxer, D.H., Giordano, G. Mol. Microbiol. (1996) [Pubmed]
The narJ gene product is required for biogenesis of respiratory nitrate reductase in Escherichia coli. Dubourdieu, M., DeMoss, J.A. J. Bacteriol. (1992) [Pubmed]

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