Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

feaB - phenylacetaldehyde dehydrogenase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1382, JW1380, padA, ydbG

Hanlon, S.P. et al., Ferrandez, A. et al., Parrott, S. et al., Barthelmebs, L. et al., Panke, S. et al.

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Disease relevance of feaB

A gene encoding phenylacetaldehyde dehydrogenase (PAD), the enzyme involved together with a copper-topaquinone-containing amine oxidase in the initial steps of 2-phenylethylamine catabolism, was located at 31.1 min on the Escherichia coli K-12 genetic map [1].
A second ORF was located just downstream of the padA gene and displayed 37% identity with the product of the Bacillus subtilis yfiO gene [2].

High impact information on feaB

Sequence homology analysis of StyD indicated a probable function as a phenylacetaldehyde dehydrogenase [3].
The padA gene encoding the phenylacetaldehyde dehydrogenase involved in the catabolism of 2-phenylethylamine in Escherichia coli has been cloned, sequenced, and located at 31.0 min on the chromosome [4].

Associations of feaB with chemical compounds

Mutants defective in phenylacetaldehyde dehydrogenase cannot grow on 2-phenylethylamine as carbon and energy source but can still use it as a nitrogen source [5].

References

2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression. Hanlon, S.P., Hill, T.K., Flavell, M.A., Stringfellow, J.M., Cooper, R.A. Microbiology (Reading, Engl.) (1997) [Pubmed]
Inducible metabolism of phenolic acids in Pediococcus pentosaceus is encoded by an autoregulated operon which involves a new class of negative transcriptional regulator. Barthelmebs, L., Lecomte, B., Divies, C., Cavin, J.F. J. Bacteriol. (2000) [Pubmed]
Towards a biocatalyst for (S)-styrene oxide production: characterization of the styrene degradation pathway of Pseudomonas sp. strain VLB120. Panke, S., Witholt, B., Schmid, A., Wubbolts, M.G. Appl. Environ. Microbiol. (1998) [Pubmed]
Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli. Ferrandez, A., Prieto, M.A., Garcia, J.L., Diaz, E. FEBS Lett. (1997) [Pubmed]
2-Phenylethylamine catabolism by Escherichia coli K12. Parrott, S., Jones, S., Cooper, R.A. J. Gen. Microbiol. (1987) [Pubmed]

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