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Gene Review:

tynA - tyramine oxidase, copper-requiring

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1383, JW1381, maoA

Steinebach, V. et al., Cooper, R.A.

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Disease relevance of tynA

The gene that encodes aromatic amine oxidase (maoA) was isolated, sequenced, and expressed in E. coli TG2 [1].
The mao operon of Escherichia coli W3350, which comprises the genes maoC and maoA, was cloned and appeared to be similar to that of Klebsiella aerogenes [Sugino, H., Sasaki, M., Azakami, H., Yamashita, M. & Murooka, Y. (1992) J. Bacteriol. 174, 2485-2492] [1].

High impact information on tynA

However, as described here, whole cells and cell-free extracts of K. aerogenes W70 showed only the tyramine oxidase (TynA) that is inactive against 2-phenylethylamine and not the maoA gene product [2].

References

Cloning of the maoA gene that encodes aromatic amine oxidase of Escherichia coli W3350 and characterization of the overexpressed enzyme. Steinebach, V., Benen, J.A., Bader, R., Postma, P.W., De Vries, S., Duine, J.A. Eur. J. Biochem. (1996) [Pubmed]
On the amine oxidases of Klebsiella aerogenes strain W70. Cooper, R.A. FEMS Microbiol. Lett. (1997) [Pubmed]

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