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Gene Review

aroH  -  3-deoxy-D-arabino-heptulosonate-7...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1702, JW1694
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Disease relevance of aroH


High impact information on aroH

  • There is significant identity in the nucleotide sequences of aroG and aroH (the gene for 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase (trp), indicating that these two genes have evolved from a common ancestral gene [2].
  • In order to explore DNA sites influenced by the trp repressor-operator interaction, bromodeoxyuridine (BrdU) was chemically incorporated into the TrpEDCBA, TrpR, and aroH operators at selected thymidine positions [3].
  • In vitro chemical mutagenesis of the cloned aroH gene was used to identify residues and regions of the polypeptide essential for catalytic activity and for tryptophan feedback regulation [4].


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