Disease relevance of tyrP

• Mutational analysis of repression and activation of the tyrP gene in Escherichia coli [1].
• State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum [2].

High impact information on tyrP

• The tyrP gene of Escherichia coli encodes a tyrosine specific transporter [3].
• A subsequent gel shift assay using a tyrP fragment which eliminates the upstream RNAP binding site confirms conclusively that, in the presence of tyrosine and ATP, the TyrR protein prevents RNAP from binding to the tyrP promoter [3].
• Binding of TyrR protein to the upstream TyrR box in the presence of phenylalanine is shown to increase the affinity of RNAP for the promoter and stimulate open complex formation at the -10 region of the tyrP promoter [3].
• Highly conserved glycine residues within span I and span II of the phenylalanine and tyrosine transporter PheP were shown to be important for the function of the wild-type protein [4].
• Importance of the position of TYR R boxes for repression and activation of the tyrP and aroF genes in Escherichia coli [5].

Biological context of tyrP

• The nucleotide sequence of 1,947 bases of DNA containing the tyrP structural gene was determined, and an open reading frame of 1,260 nucleotides was identified [6].

References