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Gene Review

tyrP  -  tyrosine transporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1906, JW1895
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Disease relevance of tyrP


High impact information on tyrP

  • The tyrP gene of Escherichia coli encodes a tyrosine specific transporter [3].
  • A subsequent gel shift assay using a tyrP fragment which eliminates the upstream RNAP binding site confirms conclusively that, in the presence of tyrosine and ATP, the TyrR protein prevents RNAP from binding to the tyrP promoter [3].
  • Binding of TyrR protein to the upstream TyrR box in the presence of phenylalanine is shown to increase the affinity of RNAP for the promoter and stimulate open complex formation at the -10 region of the tyrP promoter [3].
  • Highly conserved glycine residues within span I and span II of the phenylalanine and tyrosine transporter PheP were shown to be important for the function of the wild-type protein [4].
  • Importance of the position of TYR R boxes for repression and activation of the tyrP and aroF genes in Escherichia coli [5].

Biological context of tyrP


  1. Mutational analysis of repression and activation of the tyrP gene in Escherichia coli. Andrews, A.E., Lawley, B., Pittard, A.J. J. Bacteriol. (1991) [Pubmed]
  2. State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. Quick, M., Yano, H., Goldberg, N.R., Duan, L., Beuming, T., Shi, L., Weinstein, H., Javitch, J.A. J. Biol. Chem. (2006) [Pubmed]
  3. Mode of action of the TyrR protein: repression and activation of the tyrP promoter of Escherichia coli. Yang, J., Hwang, J.S., Camakaris, H., Irawaty, W., Ishihama, A., Pittard, J. Mol. Microbiol. (2004) [Pubmed]
  4. Putative interhelical interactions within the PheP protein revealed by second-site suppressor analysis. Dogovski, C., Pi, J., Pittard, A.J. J. Bacteriol. (2003) [Pubmed]
  5. Importance of the position of TYR R boxes for repression and activation of the tyrP and aroF genes in Escherichia coli. Andrews, A.E., Dickson, B., Lawley, B., Cobbett, C., Pittard, A.J. J. Bacteriol. (1991) [Pubmed]
  6. DNA sequence of the gene (tyrP) encoding the tyrosine-specific transport system of Escherichia coli. Wookey, P.J., Pittard, A.J. J. Bacteriol. (1988) [Pubmed]
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