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Gene Review:

sdiA - quorum-sensing transcriptional activator

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1915, JW1901, uvrX

Wang, X.D. et al., Ahmer, B.M. et al.

Ahmer, van Reeuwijk, Timmers, Valentine, Heffron,

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Disease relevance of sdiA

In this report, we have cloned the Salmonella typhimurium homolog of SdiA and performed a systematic screen for sdiA-regulated genes [1].
The gene encoding one LuxR family member, named sdiA (suppressor of cell division inhibition), is present in the Escherichia coli genome [1].

High impact information on sdiA

In addition, the sdiA gene product suppressed the action of other chromosomally encoded division inhibitors, induced minicell formation in wild type cells, and restored division activity to an ftsZ temperature-sensitive mutant grown under nonpermissive conditions [2].
The sdiA gene product is the first factor thus far identified that specifically regulates expression of this key group of cell division genes [2].
All of these properties were explained by the ability of the sdiA gene product specifically to increase transcription of the ftsQAZ gene cluster, resulting in an increase in cellular concentration of the FtsZ protein [2].

References

Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid. Ahmer, B.M., van Reeuwijk, J., Timmers, C.D., Valentine, P.J., Heffron, F. J. Bacteriol. (1998) [Pubmed]
A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli. Wang, X.D., de Boer, P.A., Rothfield, L.I. EMBO J. (1991) [Pubmed]

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