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Gene Review

fliI  -  flagellum-specific ATP synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1939, JW1925, flaC
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Disease relevance of fliI

  • The V. parahaemolyticus polar flaC flagellin gene was poorly expressed in Escherichia coli Production of FlaC was stimulated by provision of the flaA locus in trans [1].

High impact information on fliI

  • Two copies of the flagellin gene were identified: genes fla A and fla B consisted of 1731 base pairs each, occurred as tandem repeats, and were 95% identical [2].
  • We conclude that the amino acids M23, W151, G257, A295 and G377 of the E. coli lactose carrier play either a direct or an indirect role in sugar recognition and accumulation [3].
  • Interestingly, a previously isolated flagellar mutant (fliI) that expresses, but does not assemble, flagellin did not replicate in macrophages, and induced macrophage death [4].

Analytical, diagnostic and therapeutic context of fliI

  • Site-directed mutagenesis of conserved amino acids of transmembrane helix VIII indicated that residues N373, G377, S382, and R389 are functionally important [5].


  1. Vibrio parahaemolyticus FlaJ, a homologue of FliS, is required for production of a flagellin. Stewart, B.J., McCarter, L.L. Mol. Microbiol. (1996) [Pubmed]
  2. Structural and functional analysis of two Campylobacter jejuni flagellin genes. Nuijten, P.J., van Asten, F.J., Gaastra, W., van der Zeijst, B.A. J. Biol. Chem. (1990) [Pubmed]
  3. Mutants of the lactose carrier of Escherichia coli which show altered sugar recognition plus a severe defect in sugar accumulation. Varela, M.F., Wilson, T.H., Rodon-Rivera, V., Shepherd, S., Dehne, T.A., Rector, A.C. J. Membr. Biol. (2000) [Pubmed]
  4. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. Ren, T., Zamboni, D.S., Roy, C.R., Dietrich, W.F., Vance, R.E. PLoS Pathog. (2006) [Pubmed]
  5. A molecular coupling mechanism for the oxaloacetate decarboxylase Na+ pump as inferred from mutational analysis. Jockel, P., Schmid, M., Steuber, J., Dimroth, P. Biochemistry (2000) [Pubmed]
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