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Gene Review

fliP  -  flagellar biosynthesis protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1946, JW1932, flaR
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Disease relevance of fliP

  • fliP influences Citrobacter koseri macrophage uptake, cytokine expression and brain abscess formation in the neonatal rat [1].
  • We report the identification of a previously unknown Listeria monocytogenes gene, flaR, which modulates DNA topology [2].
  • When expressed in Escherichia coli, flaR encodes a protein of 18 kDa (FlaR) whose transcription is osmoregulated [2].

High impact information on fliP

  • The transposon had inserted in flaR, an open reading frame of 531 bp, followed by a second open reading frame of 1252 bp in reverse orientation [2].
  • On the basis of DNA sequence analysis and in vivo protein expression, it appears that the fliP gene product is synthesized as a precursor protein with an N-terminal signal peptide of 21 amino acids [3].
  • In minicell preparations, the flaAII.3 and flaR products were found principally in the cytoplasmic fraction; the rest were found principally in the membrane fraction [4].
  • The flaR promoter region contains putative LysR binding motifs and two putative Fur boxes [5].

Analytical, diagnostic and therapeutic context of fliP


  1. fliP influences Citrobacter koseri macrophage uptake, cytokine expression and brain abscess formation in the neonatal rat. Townsend, S.M., Gonzalez-Gomez, I., Badger, J.L. J. Med. Microbiol. (2006) [Pubmed]
  2. Modulation of DNA topology by flaR, a new gene from Listeria monocytogenes. Sanchez-Campillo, M., Dramsi, S., Gómez-Gómez, J.M., Michel, E., Dehoux, P., Cossart, P., Baquero, F., Pérez-Díaz, J.C. Mol. Microbiol. (1995) [Pubmed]
  3. Molecular characterization, nucleotide sequence, and expression of the fliO, fliP, fliQ, and fliR genes of Escherichia coli. Malakooti, J., Ely, B., Matsumura, P. J. Bacteriol. (1994) [Pubmed]
  4. Identification and characterization of the products of six region III flagellar genes (flaAII.3 through flaQII) of Salmonella typhimurium. Homma, M., Iino, T., Macnab, R.M. J. Bacteriol. (1988) [Pubmed]
  5. Cloning and characterization of a Legionella pneumophila-specific gene encoding a member of the LysR family of transcriptional regulators. Heuner, K., Dietrich, C., Steinert, M., Göbel, U.B., Hacker, J. Mol. Gen. Genet. (2000) [Pubmed]
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