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Disease relevance of Listeria


Psychiatry related information on Listeria


High impact information on Listeria

  • In the case of Listeria monocytogenes, the gene products responsible for virulence and for the introduction of antigens into the MHC class I pathway are being characterized [8].
  • Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin [9].
  • InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase [10].
  • Eukaryotic expression vectors containing truncated genes of ActA and listeriolysin--two virulence factors of Listeria monocytogenes--have been used to transform S. typhimurium aroA [11].
  • The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization [12].

Chemical compound and disease context of Listeria


Biological context of Listeria

  • Mice immunized with virulent Listeria monocytogenes generate CD8+ CTL with alpha beta receptors specific for a bacterial peptide presented by a conserved class I molecule encoded in the M region of the major histocompatibility complex [13].
  • The inlA region was localized by transposon mutagenesis, cloned, and sequenced. inlA was introduced into Listeria innocua and shown to confer on this normally noninvasive species the ability to enter cells [17].
  • Here, we show that tumor necrosis factor receptor p55-/- (TRp55-/-) mice are susceptible to Listeria monocytogenes infection in the presence of leukocyte recruitment, inflammatory cytokine production (including IFNgamma), nitric oxide synthesis, and oxidative burst formation [18].
  • Mice of the H-2 d, H-2 b,and H-2 k haplotypes respond to this peptide upon infection with Listeria monocytogenes [19].
  • InlB, a surface-localized protein of Listeria monocytogenes, induces phagocytosis in non-phagocytic mammalian cells by activating Met, a receptor tyrosine kinase [20].

Anatomical context of Listeria


Gene context of Listeria

  • Here we use flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse T-cell production of IFN-gamma and IL-4 from mice infected with Listeria monocytogenes or Nippostrongylus brasiliensis [24].
  • TCCR-deficient mice also had increased susceptibility to infection with an intracellular pathogen, Listeria monocytogenes [25].
  • Here we show that Rip2-deficient mice exhibit a profoundly decreased ability to defend against infection by the intracellular pathogen Listeria monocytogenes [26].
  • Infection with the intracellular bacterial pathogen Listeria monocytogenes induces CCR2-dependent monocyte recruitment and activation, an essential response for host survival [27].
  • A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production [15].

Analytical, diagnostic and therapeutic context of Listeria


  1. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Kägi, D., Ledermann, B., Bürki, K., Zinkernagel, R.M., Hengartner, H. Annu. Rev. Immunol. (1996) [Pubmed]
  2. Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling. Frischknecht, F., Moreau, V., Röttger, S., Gonfloni, S., Reckmann, I., Superti-Furga, G., Way, M. Nature (1999) [Pubmed]
  3. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., Takashima, Y., Kawabe, Y., Cynshi, O., Wada, Y., Honda, M., Kurihara, H., Aburatani, H., Doi, T., Matsumoto, A., Azuma, S., Noda, T., Toyoda, Y., Itakura, H., Yazaki, Y., Kodama, T. Nature (1997) [Pubmed]
  4. Intrathecal gentamicin for refractory gram-positive meningitis. Shuman, R.D., Smith, C.R. JAMA (1978) [Pubmed]
  5. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Hamerman, J.A., Tchao, N.K., Lowell, C.A., Lanier, L.L. Nat. Immunol. (2005) [Pubmed]
  6. Efficacy of ampicillin therapy in experimental listeriosis in mice with impaired T-cell-mediated immune response. Bakker-Woudenberg, I.A., de Bos, P., van Leeuwen, W.B., Michel, M.F. Antimicrob. Agents Chemother. (1981) [Pubmed]
  7. Musical auditory hallucinosis from Listeria rhombencephalitis. Douen, A.G., Bourque, P.R. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1997) [Pubmed]
  8. Immunity to intracellular bacteria. Kaufmann, S.H. Annu. Rev. Immunol. (1993) [Pubmed]
  9. Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin. Schubert, W.D., Urbanke, C., Ziehm, T., Beier, V., Machner, M.P., Domann, E., Wehland, J., Chakraborty, T., Heinz, D.W. Cell (2002) [Pubmed]
  10. InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. Shen, Y., Naujokas, M., Park, M., Ireton, K. Cell (2000) [Pubmed]
  11. Oral somatic transgene vaccination using attenuated S. typhimurium. Darji, A., Guzmán, C.A., Gerstel, B., Wachholz, P., Timmis, K.N., Wehland, J., Chakraborty, T., Weiss, S. Cell (1997) [Pubmed]
  12. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., Soriano, P. Cell (1996) [Pubmed]
  13. H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes. Pamer, E.G., Wang, C.R., Flaherty, L., Lindahl, K.F., Bevan, M.J. Cell (1992) [Pubmed]
  14. The modulation of lymphocyte functions by molecules secreted by macrophages. II. Conditions leading to increased secretion. Unanue, E.R., Kiely, J.M., Calderon, J. J. Exp. Med. (1976) [Pubmed]
  15. A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production. Neighbors, M., Xu, X., Barrat, F.J., Ruuls, S.R., Churakova, T., Debets, R., Bazan, J.F., Kastelein, R.A., Abrams, J.S., O'Garra, A. J. Exp. Med. (2001) [Pubmed]
  16. Synthesis of the second component of complement by long-term primary cultures of human monocytes. Einstein, L.P., Schneeberger, E.E., Colten, H.R. J. Exp. Med. (1976) [Pubmed]
  17. Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci. Gaillard, J.L., Berche, P., Frehel, C., Gouin, E., Cossart, P. Cell (1991) [Pubmed]
  18. Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Endres, R., Luz, A., Schulze, H., Neubauer, H., Fütterer, A., Holland, S.M., Wagner, H., Pfeffer, K. Immunity (1997) [Pubmed]
  19. A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule. Gulden, P.H., Fischer, P., Sherman, N.E., Wang, W., Engelhard, V.H., Shabanowitz, J., Hunt, D.F., Pamer, E.G. Immunity (1996) [Pubmed]
  20. GW domains of the Listeria monocytogenes invasion protein InlB are SH3-like and mediate binding to host ligands. Marino, M., Banerjee, M., Jonquières, R., Cossart, P., Ghosh, P. EMBO J. (2002) [Pubmed]
  21. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Welch, M.D., Rosenblatt, J., Skoble, J., Portnoy, D.A., Mitchison, T.J. Science (1998) [Pubmed]
  22. Intracellular antibody neutralizes Listeria growth. Edelson, B.T., Unanue, E.R. Immunity (2001) [Pubmed]
  23. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Serbina, N.V., Salazar-Mather, T.P., Biron, C.A., Kuziel, W.A., Pamer, E.G. Immunity (2003) [Pubmed]
  24. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Ferrick, D.A., Schrenzel, M.D., Mulvania, T., Hsieh, B., Ferlin, W.G., Lepper, H. Nature (1995) [Pubmed]
  25. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.H., Gurney, A., Grewal, I.S., de Sauvage, F.J. Nature (2000) [Pubmed]
  26. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Chin, A.I., Dempsey, P.W., Bruhn, K., Miller, J.F., Xu, Y., Cheng, G. Nature (2002) [Pubmed]
  27. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. Serbina, N.V., Kuziel, W., Flavell, R., Akira, S., Rollins, B., Pamer, E.G. Immunity (2003) [Pubmed]
  28. Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: role of CD8+ T cells and IL-18. Hansen, G., Yeung, V.P., Berry, G., Umetsu, D.T., DeKruyff, R.H. J. Immunol. (2000) [Pubmed]
  29. The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis. Zerrahn, J., Schaible, U.E., Brinkmann, V., Guhlich, U., Kaufmann, S.H. J. Immunol. (2002) [Pubmed]
  30. An update on the efficacy of ciprofloxacin in animal models of infection. Andriole, V.T. Am. J. Med. (1989) [Pubmed]
  31. Listeria monocytogenes: brain abscess or meningoencephalitis? Lechtenberg, R., Sierra, M.F., Pringle, G.F., Shucart, W.A., Butt, K.M. Neurology (1979) [Pubmed]
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