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Gene Review

hisH  -  imidazole glycerol phosphate synthase,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2018, JW2005
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Disease relevance of hisH

  • The cloned hisH product was purified from E. coli and estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to have a molecular mass of 40,000 Da [1].
  • hisH encodes imidazole acetol phosphate (IAP) aminotransferase in Zymomonas mobilis and is located immediately upstream of tyrC, a gene which codes for cyclohexadienyl dehydrogenase [1].

High impact information on hisH

  • A further 3 ORFs not thought to be involved with LPS synthesis were identified (hisH, hisF, and uvrB) [2].
  • The second protein encoded by the hisH gene exhibits no detectable catalytic properties with biosynthetic intermediate PRFAR, glutamine, or ammonia [3].
  • Information available from structural and functional genomics studies was used to improve the structure prediction, to discuss parallels between histidine biosynthesis and other amino acid and nucleotide metabolic pathways, and to better understand the protein-protein interactions between the hisH and hisF domains of IGPS [4].
  • On the structure of hisH: protein structure prediction in the context of structural and functional genomics [4].
  • DNA sequencing of hisH revealed an open reading frame of 1,110 bp, encoding a protein of 40,631 Da [1].

Chemical compound and disease context of hisH


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