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Gene Review

uvrB  -  exision nuclease of nucleotide excision...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0768, JW0762, dar-1, dar-6
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Disease relevance of uvrB


High impact information on uvrB


Chemical compound and disease context of uvrB


Biological context of uvrB


Associations of uvrB with chemical compounds

  • In such cells pyrimidine dimers are tolerated by a rather error-free process that depends on the activity of uvrB, recA and lexA genes [18].
  • The protein sequence was determined from the DNA sequence of the uvrB gene and was confirmed by sequencing the NH2-terminus of the UvrB protein and analyzing its overall amino acid composition [19].
  • Combination of these mutations in the recB21recF143 double mutant blocks W-reactivation completely after BM induction, but leaves residual W-reactivation ability after UV-irradiation, which is abolished by the introduction of uvrB deficiency (delta(uvrB-chlA] [20].
  • Results of transformation assays indicated that the uvrB gene function was essential for repair of plasmid DNA damaged with cis-DDP [21].

Other interactions of uvrB

  • The uvrA gene is located on the pAD1 map between 28.1 and 29.4 kb. uvrB is located between 30.1 and 30.3 kb, and uvrC is located between 30.4 and 30.6 kb on the pAD1 map [14].
  • uvrB-dependent, recF-independent post-replication (or replication) repair in Escherichia coli [22].


  1. Survival of Shewanella oneidensis MR-1 after UV radiation exposure. Qiu, X., Sundin, G.W., Chai, B., Tiedje, J.M. Appl. Environ. Microbiol. (2004) [Pubmed]
  2. Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli. Parniewski, P., Bacolla, A., Jaworski, A., Wells, R.D. Nucleic Acids Res. (1999) [Pubmed]
  3. Evidence for a Micrococcus luteus gene homologous to uvrB of Escherichia coli. Shiota, S., Nakayama, H. Mol. Gen. Genet. (1988) [Pubmed]
  4. Effects of the antimutagen cinnamaldehyde on reversion and survival of selected Salmonella tester strains. de Silva, H.V., Shankel, D.M. Mutat. Res. (1987) [Pubmed]
  5. Stimulation of mutations suppressing the loss of replication control by small alcohols. Hayes, S., Hayes, C., Duncan, D., Bennett, V., Blushke, J. Mutat. Res. (1990) [Pubmed]
  6. Biochemical analysis of UV mutagenesis in Escherichia coli by using a cell-free reaction coupled to a bioassay: identification of a DNA repair-dependent, replication-independent pathway. Cohen-Fix, O., Livneh, Z. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. Rapid and apparently error-prone excision repair of nonreplicating UV-irradiated plasmids in Xenopus laevis oocytes. Hays, J.B., Ackerman, E.J., Pang, Q.S. Mol. Cell. Biol. (1990) [Pubmed]
  8. Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster. Burrows, L.L., Charter, D.F., Lam, J.S. Mol. Microbiol. (1996) [Pubmed]
  9. The E. coli uvrB gene and the rat cytochrome c pseudogene. Homology or cloning artefact? Goosen, N., Backendorf, C. Nucleic Acids Res. (1987) [Pubmed]
  10. Structure of the uvrB gene of Escherichia coli. Homology with other DNA repair enzymes and characterization of the uvrB5 mutation. Backendorf, C., Spaink, H., Barbeiro, A.P., van de Putte, P. Nucleic Acids Res. (1986) [Pubmed]
  11. The influence of local DNA sequence and DNA repair background on the mutational specificity of 1-nitroso-8-nitropyrene in Escherichia coli: inferences for mutagenic mechanisms. Lambert, I.B., Gordon, A.J., Glickman, B.W., McCalla, D.R. Genetics (1992) [Pubmed]
  12. The mutational specificity of furazolidone in the lacI gene of Escherichia coli. Bertenyi, K.K., Lambert, I.B. Mutat. Res. (1996) [Pubmed]
  13. Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli. Veigl, M.L., Donover, S.P., Anderson, R.D., Akst, L., Sedwick, C.E., Sedwick, W.D. Environ. Mol. Mutagen. (1995) [Pubmed]
  14. Cloning and genetic analysis of the UV resistance determinant (uvr) encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pAD1. Ozawa, Y., Tanimoto, K., Fujimoto, S., Tomita, H., Ike, Y. J. Bacteriol. (1997) [Pubmed]
  15. Induction of genotoxic effects by chlorohydroxyfuranones, byproducts of water disinfection, in E. coli K-12 cells recovered from various organs of mice. Fekadu, K., Parzefall, W., Kronberg, L., Franzen, R., Schulte-Hermann, R., Knasmüller, S. Environ. Mol. Mutagen. (1994) [Pubmed]
  16. Mutagenic DNA repair in Escherichia coli, XX. Overproduction of UmuD' protein results in suppression of the umuC36 mutation in excision defective bacteria. Bates, H., Bridges, B.A., Woodgate, R. Mutat. Res. (1991) [Pubmed]
  17. Isolation and characterization of visible light-sensitive mutants of Escherichia coli K12. Miyamoto, K., Nakahigashi, K., Nishimura, K., Inokuchi, H. J. Mol. Biol. (1991) [Pubmed]
  18. DNA repair in Escherichia coli: the dual function of uvr genes. Masek, F., Fridrichova, I., Pirsel, M., Sedliaková, M. Neoplasma (1995) [Pubmed]
  19. Sequences of the E. coli uvrB gene and protein. Arikan, E., Kulkarni, M.S., Thomas, D.C., Sancar, A. Nucleic Acids Res. (1986) [Pubmed]
  20. Participation of rec genes of Escherichia coli K 12 in W-reactivation of UV-irradiated phage lambda. Simić, D., Vuković-Gacić, B., Knezević-Vukcević, J. Mutat. Res. (1990) [Pubmed]
  21. Repair of plasmid DNA damaged in vitro with cis- or trans-diamminedichloroplatinum(II) in Escherichia coli. Popoff, S.C., Beck, D.J., Rupp, W.D. Mutat. Res. (1987) [Pubmed]
  22. uvrB-dependent, recF-independent post-replication (or replication) repair in Escherichia coli. Slezáriková, V., Sedliaková, M. J. Photochem. Photobiol. B, Biol. (1991) [Pubmed]
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