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Gene Review: 

baeR  -  response regulator in two-component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2075, JW2064
 
 
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Disease relevance of baeR

  • Screening of random fragments of Escherichia coli genomic DNA for their ability to increase the novobiocin resistance of a hypersusceptible (Delta)acrAB mutant resulted in the isolation of a plasmid containing baeR, which codes for the response regulator of the two-component regulatory system BaeSR [1].
 

High impact information on baeR

  • The drug resistance mediated by evgA, baeR, and cpxR could be assigned to drug exporters by using drug exporter gene knockout strains [2].
  • One (pSN11) is located around 45 min on the E. coli genetic map, that contains two adjacent coding-sequences (baeS and baeR) [3].
 

Associations of baeR with chemical compounds

  • When induced for expression, baeR cloned in multicopy plasmid pTrc99A significantly increased the resistance of the (Delta)acrAB host strain to novobiocin (16-fold) and to deoxycholate (8-fold) [1].

References

  1. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova, N., Nikaido, H. J. Bacteriol. (2002) [Pubmed]
  2. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa, H., Nishino, K., Hirata, T., Yamaguchi, A. J. Bacteriol. (2003) [Pubmed]
  3. Novel members of the two-component signal transduction genes in Escherichia coli. Nagasawa, S., Ishige, K., Mizuno, T. J. Biochem. (1993) [Pubmed]
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