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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rppH  -  RNA pyrophosphohydrolase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2826, JW2798, nudH, ygdP
 
 
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Disease relevance of nudH

  • The gene ygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5')-pentaphospho-(5')-adenosine (Ap5A) [1].
  • ygdP, a gene associated with the invasion of brain microvascular endothelial cells by Escherichia coli K1 (Badger, J. L., Wass, C. A., and Kim, K. S. (2000) Mol. Microbiol. 36, 174-182), the primary Gram-negative bacterium causing meningitis in newborns, has been cloned and expressed in E. coli [1].
  • The ygdP and apaH genes of Salmonella enterica serovar Typhimurium (S. Typhimurium) encode two unrelated dinucleoside polyphosphate (NpnN) hydrolases [2].
  • One such clone, containing a ygdP promoter and an open reading frame (ORF), showed significant homology to Bartonella bacilliformis IalA (invasion associated locus) [3].
 

High impact information on nudH

  • The normal level of 3 microM adenylated NpnN (ApnN) was increased 1.5-, 3.5-, and 10-fold in the ygdP, apaH and double mutants, respectively [2].
  • Expression of the putative ptsP virulence gene downstream of ygdP was not affected in the ygdP mutant [2].
 

Anatomical context of nudH

  • Disruption of ygdP, apaH individually, and disruption of both genes together reduced intracellular invasion of human HEp-2 epithelial cells by S [2].

References

  1. The gene ygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5')-pentaphospho-(5')-adenosine (Ap5A). Bessman, M.J., Walsh, J.D., Dunn, C.A., Swaminathan, J., Weldon, J.E., Shen, J. J. Biol. Chem. (2001) [Pubmed]
  2. Regulation of dinucleoside polyphosphate pools by the YgdP and ApaH hydrolases is essential for the ability of Salmonella enterica serovar typhimurium to invade cultured mammalian cells. Ismail, T.M., Hart, C.A., McLennan, A.G. J. Biol. Chem. (2003) [Pubmed]
  3. Identification of Escherichia coli K1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction. Badger, J.L., Wass, C.A., Kim, K.S. Mol. Microbiol. (2000) [Pubmed]
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