Disease relevance of glyU

• Effect of enhanced synthesis of the epsilon subunit of DNA polymerase III on spontaneous and UV-induced mutagenesis of the Escherichia coli glyU gene [1].
• In this paper, phage glyU anticodon mutants are detected by their ability to suppress GAA and GAT missense mutations in trpA [2].
• Effect of DNA sequence changes on UV mutability of a purine anticodon triplet of glyU cloned on M13 phage [3].

High impact information on glyU

• It contains the entire primary nucleotide sequences of tRNA Gly2 suA36 and tRNA Thr ACU/C, including the common 3'-terminal sequence, CCA [4].
• The 170-nucleotide precursor RNA is processed by E. coli extracts to form mature tRNA Gly 2 suA36 and tRNA Thr ACU/C [4].
• Previous reports have recognized the presence of a type III secretion system (T3SS), designated ETT2, at the glyU locus of prototype EAEC strain 042, along with possible T3SS effectors at the selC locus [5].

Biological context of glyU

• The nucleotide sequence of glyU and its flanking regions is presented [2].

References