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Gene Review

mscL  -  mechanosensitive channel protein, high...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3277, JW3252, stkA, yhdC
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Disease relevance of mscL


High impact information on mscL

  • Insertional disruption of mscL removes the channel activity, whereas re-expression of mscL borne on an expression plasmid restores it [1].
  • The mscL nucleotide sequence predicts a unique protein of only 136 amino acids, with a highly hydrophobic core and very different from porins or other known proteins [1].
  • One gene, mscL, encoding a large conductance channel has previously been described, but null mutants were without well-defined phenotypes [4].
  • Using chromatographies to enrich the target and patch clamp to assay the channel activity in liposome-reconstituted fractions, we identified the MscL protein and cloned the mscL gene [5].
  • Reduced levels of MS proteins and reduced expression of mscL- and mscS-LacZ fusions in an rpoS mutant strain suggested that the RNA polymerase holoenzyme containing sigmaS is responsible, at least in part, for regulating production of MS channel proteins [6].


  1. A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Sukharev, S.I., Blount, P., Martinac, B., Blattner, F.R., Kung, C. Nature (1994) [Pubmed]
  2. Identification of the gene encoding a mechanosensitive channel MscL homologue in Clostridium perfringens. Matsushita, O., Jung, C.M., Okabe, A. Gene (1995) [Pubmed]
  3. Mechanosensitive channel functions to alleviate the cell lysis of marine bacterium, Vibrio alginolyticus, by osmotic downshock. Nakamaru, Y., Takahashi, Y., Unemoto, T., Nakamura, T. FEBS Lett. (1999) [Pubmed]
  4. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina, N., Tötemeyer, S., Stokes, N.R., Louis, P., Jones, M.A., Booth, I.R. EMBO J. (1999) [Pubmed]
  5. Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities. Sukharev, S.I., Blount, P., Martinac, B., Kung, C. Annu. Rev. Physiol. (1997) [Pubmed]
  6. A role for mechanosensitive channels in survival of stationary phase: regulation of channel expression by RpoS. Stokes, N.R., Murray, H.D., Subramaniam, C., Gourse, R.L., Louis, P., Bartlett, W., Miller, S., Booth, I.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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