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Gene Review

rpe  -  D-ribulose-5-phosphate 3-epimerase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3373, JW3349, dod, yhfD
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Disease relevance of rpe

  • Downstream of the dam gene in the Escherichia coli genome the following three genes are located: first rpe, then a gene encoding a 27 kDa protein and finally trpS [1].

High impact information on rpe

  • In separate experiments, we have shown that the 24 kDa protein has d-ribulose-5-phosphate epimerase activity (similar to CbbE), and we call the gene rpe [2].
  • The recently identified gene for ribulose-5-phosphate 3-epimerase (rpe) is part of a large operon that comprises among other genes for the biosynthesis of aromatic amino acids [3].
  • Growth of the rpe mutant is impaired in complex LB medium and severely impaired in minimal medium containing glycolytic carbon sources or gluconate [4].

Chemical compound and disease context of rpe


  1. The gene for 2-phosphoglycolate phosphatase (gph) in Escherichia coli is located in the same operon as dam and at least five other diverse genes. Lyngstadaas, A., Løbner-Olesen, A., Grelland, E., Boye, E. Biochim. Biophys. Acta (1999) [Pubmed]
  2. Characterization of three genes in the dam-containing operon of Escherichia coli. Lyngstadaas, A., Løbner-Olesen, A., Boye, E. Mol. Gen. Genet. (1995) [Pubmed]
  3. Genetics of pentose-phosphate pathway enzymes of Escherichia coli K-12. Sprenger, G.A. Arch. Microbiol. (1995) [Pubmed]
  4. Impaired growth of an Escherichia coli rpe mutant lacking ribulose-5-phosphate epimerase activity. Lyngstadaas, A., Sprenger, G.A., Boye, E. Biochim. Biophys. Acta (1998) [Pubmed]
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