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Gene Review

trpS  -  tryptophanyl-tRNA synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3371, JW3347
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Disease relevance of trpS


Psychiatry related information on trpS

  • Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease [6].

High impact information on trpS


Chemical compound and disease context of trpS


Biological context of trpS


Anatomical context of trpS

  • Reaction of tryptophanyl-tRNA synthetase from beef pancreas with periodate-oxidized ATP [13].

Associations of trpS with chemical compounds


Analytical, diagnostic and therapeutic context of trpS


  1. Characterization of three genes in the dam-containing operon of Escherichia coli. Lyngstadaas, A., Løbner-Olesen, A., Boye, E. Mol. Gen. Genet. (1995) [Pubmed]
  2. A temperature-sensitive trpS mutation interferes with trp RNA-binding attenuation protein (TRAP) regulation of trp gene expression in Bacillus subtilis. Lee, A.I., Sarsero, J.P., Yanofsky, C. J. Bacteriol. (1996) [Pubmed]
  3. An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans. Buddha, M.R., Keery, K.M., Crane, B.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Escherichia coli tryptophanyl-tRNA synthetase mutants selected for tryptophan auxotrophy implicate the dimer interface in optimizing amino acid binding. Sever, S., Rogers, K., Rogers, M.J., Carter, C., Söll, D. Biochemistry (1996) [Pubmed]
  5. Control of RNA and protein synthesis by the concentration of Trp-tRNATrp in Escherichia coli infected with bacteriophage MS2. Koontz, S.W., Jakubowski, H., Goldman, E. J. Mol. Biol. (1983) [Pubmed]
  6. Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease. Paley, E.L., Smelyanski, L., Malinovskii, V., Subbarayan, P.R., Berdichevsky, Y., Posternak, N., Gershoni, J.M., Sokolova, O., Denisova, G. Mol. Immunol. (2007) [Pubmed]
  7. A Bacillus subtilis operon containing genes of unknown function senses tRNATrp charging and regulates expression of the genes of tryptophan biosynthesis. Sarsero, J.P., Merino, E., Yanofsky, C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. The nucleotide sequence of the structural gene for Escherichia coli tryptophanyl-tRNA synthetase. Hall, C.V., vanCleemput, M., Muench, K.H., Yanofsky, C. J. Biol. Chem. (1982) [Pubmed]
  9. Transfer RNA control of the activation of isomeric tRNATrp's. Alford, B.L., Hecht, S.M. J. Biol. Chem. (1979) [Pubmed]
  10. Tryptophanyl transfer ribonucleic acid synthetase of Escherichia coli. Character of required thiol group and structure of thiol peptides. Kuehl, G.V., Lee, M.L., Muench, K.H. J. Biol. Chem. (1976) [Pubmed]
  11. Crystallization of Bacillus subtilis tryptophanyl-tRNA synthetase. Ala, P., Xue, H., Leung, L., Xue, Y.Q., Wong, J.T., Yang, D.S. J. Mol. Biol. (1993) [Pubmed]
  12. Role of lysine-195 in the KMSKS sequence of E. coli tryptophanyl-tRNA synthetase. Chan, K.W., Koeppe, R.E. FEBS Lett. (1995) [Pubmed]
  13. Reaction of tryptophanyl-tRNA synthetase from beef pancreas with periodate-oxidized ATP. Fournier, M., Labouesse, B., Labouesse, J. Eur. J. Biochem. (1987) [Pubmed]
  14. The gene for 2-phosphoglycolate phosphatase (gph) in Escherichia coli is located in the same operon as dam and at least five other diverse genes. Lyngstadaas, A., Løbner-Olesen, A., Grelland, E., Boye, E. Biochim. Biophys. Acta (1999) [Pubmed]
  15. Cloning and complete nucleotide sequence of the Bacillus stearothermophilus tryptophanyl tRNA synthetase gene. Barstow, D.A., Sharman, A.F., Atkinson, T., Minton, N.P. Gene (1986) [Pubmed]
  16. Ancient adaptation of the active site of tryptophanyl-tRNA synthetase for tryptophan binding. Praetorius-Ibba, M., Stange-Thomann, N., Kitabatake, M., Ali, K., Söll, I., Carter, C.W., Ibba, M., Söll, D. Biochemistry (2000) [Pubmed]
  17. Selection and characterization of Escherichia coli variants capable of growth on an otherwise toxic tryptophan analogue. Bacher, J.M., Ellington, A.D. J. Bacteriol. (2001) [Pubmed]
  18. Overproduction of tryptophanyl-tRNA synthetase relieves transcription termination at the Escherichia coli tryptophan operon attenuator. Das, A., Yanofsky, C. J. Bacteriol. (1984) [Pubmed]
  19. Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli. Bogosian, G., Haydock, P.V., Somerville, R.L. J. Bacteriol. (1983) [Pubmed]
  20. Interdomain interactions in oligomeric enzymes: creation of asymmetry in homo-oligomers and role in metabolite channeling between active centers of hetero-oligomers. Nagradova, N.K. FEBS Lett. (2001) [Pubmed]
  21. Blue dextran Sepharose chromatography of the tryptophanyl-tRNA synthetase of E. coli: a potential application for the purification of the enzyme. Drocourt, J.L., Thang, D.C., Buckingham, R.H., Thang, M.N. Nucleic Acids Res. (1979) [Pubmed]
  22. Tryptophanyl adenylate formation by tryptophanyl-tRNA synthetase from Escherichia coli. Merle, M., Trezeguet, V., Graves, P.V., Andrews, D., Muench, K.H., Labouesse, B. Biochemistry (1986) [Pubmed]
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