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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

bcsA  -  cellulose synthase, catalytic subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3518, JW5665, yhjO, yhjP
 
 
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Disease relevance of bcsA

  • Control of expression by the cellulose synthase (bcsA) promoter region from Acetobacter xylinum BPR 2001 [1].
  • Here, we showed using in vivo and in vitro experiments that the Crl protein of Salmonella serovar Typhimurium is required for development of a typical rdar morphotype and for maximal expression of the csgD, csgB, adrA, and bcsA genes, which are involved in curli and cellulose biosynthesis [2].
 

High impact information on bcsA

  • The four genes--bcsA, bcsB, bcsC, and bcsD--appear to be translationally coupled and transcribed as a polycistronic mRNA with an initiation site 97 bases upstream of the coding region of the first gene (bcsA) in the operon [3].
 

Other interactions of bcsA

  • The functions of the bcsA, bcsC, and bcsD gene products are unknown [3].

References

  1. Control of expression by the cellulose synthase (bcsA) promoter region from Acetobacter xylinum BPR 2001. Nakai, T., Moriya, A., Tonouchi, N., Tsuchida, T., Yoshinaga, F., Horinouchi, S., Sone, Y., Mori, H., Sakai, F., Hayashi, T. Gene (1998) [Pubmed]
  2. Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium. Robbe-Saule, V., Jaumouillé, V., Prévost, M.C., Guadagnini, S., Talhouarne, C., Mathout, H., Kolb, A., Norel, F. J. Bacteriol. (2006) [Pubmed]
  3. Genetic organization of the cellulose synthase operon in Acetobacter xylinum. Wong, H.C., Fear, A.L., Calhoon, R.D., Eichinger, G.H., Mayer, R., Amikam, D., Benziman, M., Gelfand, D.H., Meade, J.H., Emerick, A.W. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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