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Gene Review:

tnaB - tryptophan transporter of low affinity

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3702, JW5619, JW5622, tnaP, trpP

Manson, M.D. et al., Yanofsky, C. et al., Kamath, A.V. et al.

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Disease relevance of tnaB

A copy of insertion element IS5 is present within tnaB in the Kohara library of Escherichia coli W3110 [1].

High impact information on tnaB

However, when 1-methyltryptophan replaces tryptophan as the inducer in this medium, mutations in both mtr and tnaB are required to prevent maximum induction [2].
We also discovered a pleiotropic site trpP (S) that maps outside the structural gene region and is closely linked to the S. dysenteriae trp operator. trpP (S) reduced the rate of trp messenger ribonucleic acid synthesis, and consequently trp enzyme levels, 10-fold relative to wild-type E. coli [3].
Thus, the Trp auxotrophy associated with the S dysenteriae trp operon derives from the combination of a defective ASase and decreased expression of the entire operon imposed by trpP (S) [3].

References

A copy of insertion element IS5 is present within tnaB in the Kohara library of Escherichia coli W3110. Kamath, A.V., Gish, K., Yanofsky, C. J. Bacteriol. (1994) [Pubmed]
Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli. Yanofsky, C., Horn, V., Gollnick, P. J. Bacteriol. (1991) [Pubmed]
Naturally occurring sites within the Shigella dysenteriae tryptophan operon severely limit tryptophan biosynthesis. Manson, M.D., Yanofsky, C. J. Bacteriol. (1976) [Pubmed]

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