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Gene Review

tnaB  -  tryptophan transporter of low affinity

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3702, JW5619, JW5622, tnaP, trpP
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Disease relevance of tnaB


High impact information on tnaB

  • However, when 1-methyltryptophan replaces tryptophan as the inducer in this medium, mutations in both mtr and tnaB are required to prevent maximum induction [2].
  • We also discovered a pleiotropic site trpP (S) that maps outside the structural gene region and is closely linked to the S. dysenteriae trp operator. trpP (S) reduced the rate of trp messenger ribonucleic acid synthesis, and consequently trp enzyme levels, 10-fold relative to wild-type E. coli [3].
  • Thus, the Trp auxotrophy associated with the S dysenteriae trp operon derives from the combination of a defective ASase and decreased expression of the entire operon imposed by trpP (S) [3].


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